Etiologic studies of epidemic hemorrhagic fever (hemorrhagic fever with renal syndrome).

Journal Article (Journal Article)

Two strains of epidemic hemorrhagic fever (EHF) virus were isolated from the lung tissues of Apodemus agrarius mice that were captured in an area where EHF is endemic. The strains were isolated by passages in A. agrarius mice from a nonendemic area. Identification of the isolates by usual procedures was confirmed by repeated blind tests with coded sera. Contamination with certain known viruses such as reovirus, adenovirus (types 3 and 7), and other pathogens, such as murine typhus rickettsiae and Leptospira, which may be naturally present in wild rodents, appeared to have been ruled out. The antigen slides made from these isolates are in use in the specific diagnosis and seroepidemiologic studies of EHF. The first successful application is the serodiagnosis of a mild type of hemorrhagic fever that occurs with characteristic epidemiologic features in certain provinces of China.

Full Text

Duke Authors

Cited Authors

  • Song, G; Hang, CS; Qui, XZ; Ni, DS; Liao, HX; Gao, GZ; Du, YL; Xu, JK; Wu, YS; Zhao, JN; Kong, BX; Wang, ZS; Zhang, ZQ; Shen, HK; Zhou, N

Published Date

  • April 1, 1983

Published In

Volume / Issue

  • 147 / 4

Start / End Page

  • 654 - 659

PubMed ID

  • 6132949

International Standard Serial Number (ISSN)

  • 0022-1899

Digital Object Identifier (DOI)

  • 10.1093/infdis/147.4.654


  • eng

Conference Location

  • United States