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Principles and problems of transfusion in sickle cell disease.

Publication ,  Journal Article
Telen, MJ
Published in: Semin Hematol
October 2001

Sickle cell disease (SCD) is associated with red blood cell (RBC) abnormalities and moderate to severe anemia, and blood transfusion is naturally a mainstay of treatment. However, transfusion therapy for SCD may incur special and distinctive adverse effects. Thus, it is important to understand the indications for and goals of transfusion therapy and to be aware of the potential side effects of therapy. Years of unsystematic clinical observations, followed by more carefully designed and in some cases randomized studies, have contributed substantially to our knowledge of transfusion therapy in SCD. However, much remains unknown and areas of controversy persist. In addition, serologic barriers pose enduring roadblocks to the optimization of transfusion therapy for patients with SCD, and the syndrome of massive hemolytic transfusion reactions and hyperhemolysis in SCD persists as a life-threatening complication for which appropriate clinical management is not yet defined.

Duke Scholars

Published In

Semin Hematol

DOI

ISSN

0037-1963

Publication Date

October 2001

Volume

38

Issue

4

Start / End Page

315 / 323

Location

United States

Related Subject Headings

  • Transfusion Reaction
  • Pregnancy
  • Male
  • Immunology
  • Humans
  • Female
  • Blood Transfusion
  • Anemia, Sickle Cell
  • Acute Disease
  • 3201 Cardiovascular medicine and haematology
 

Citation

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ICMJE
MLA
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Telen, M. J. (2001). Principles and problems of transfusion in sickle cell disease. Semin Hematol, 38(4), 315–323. https://doi.org/10.1016/s0037-1963(01)90025-3
Telen, M. J. “Principles and problems of transfusion in sickle cell disease.Semin Hematol 38, no. 4 (October 2001): 315–23. https://doi.org/10.1016/s0037-1963(01)90025-3.
Telen MJ. Principles and problems of transfusion in sickle cell disease. Semin Hematol. 2001 Oct;38(4):315–23.
Telen, M. J. “Principles and problems of transfusion in sickle cell disease.Semin Hematol, vol. 38, no. 4, Oct. 2001, pp. 315–23. Pubmed, doi:10.1016/s0037-1963(01)90025-3.
Telen MJ. Principles and problems of transfusion in sickle cell disease. Semin Hematol. 2001 Oct;38(4):315–323.
Journal cover image

Published In

Semin Hematol

DOI

ISSN

0037-1963

Publication Date

October 2001

Volume

38

Issue

4

Start / End Page

315 / 323

Location

United States

Related Subject Headings

  • Transfusion Reaction
  • Pregnancy
  • Male
  • Immunology
  • Humans
  • Female
  • Blood Transfusion
  • Anemia, Sickle Cell
  • Acute Disease
  • 3201 Cardiovascular medicine and haematology