Basal cell adhesion molecule/lutheran protein. The receptor critical for sickle cell adhesion to laminin.

Journal Article (Journal Article)

Sickle red cells bind significant amounts of soluble laminin, whereas normal red cells do not. Solid phase assays demonstrate that B-CAM/LU binds laminin on intact sickle red cells and that red cell B-CAM/LU binds immobilized laminin, whereas another putative laminin binding protein, CD44, does not. Ligand blots also identify B-CAM/LU as the only erythrocyte membrane protein(s) that binds laminin. Finally, transfection of murine erythroleukemia cells with human B-CAM cDNA induces binding of both soluble and immobilized laminin. Thus, B-CAM/LU appears to be the major laminin-binding protein of sickle red cells. Previously reported overexpression of B-CAM/LU by epithelial cancer cells suggests that this protein may also serve as a laminin receptor in malignant tumors.

Full Text

Duke Authors

Cited Authors

  • Udani, M; Zen, Q; Cottman, M; Leonard, N; Jefferson, S; Daymont, C; Truskey, G; Telen, MJ

Published Date

  • June 1, 1998

Published In

Volume / Issue

  • 101 / 11

Start / End Page

  • 2550 - 2558

PubMed ID

  • 9616226

Pubmed Central ID

  • PMC508844

International Standard Serial Number (ISSN)

  • 0021-9738

Digital Object Identifier (DOI)

  • 10.1172/JCI1204


  • eng

Conference Location

  • United States