Characterization of the serum In(Lu)-related antigen: identification of a serum protein related to erythrocyte p80.


Journal Article

The In(Lu) gene has been shown previously to downregulate expression by erythrocytes and by a subset of leukocytes of an 80-Kd protein antigen defined by monoclonal antibody (MoAb) A3D8. A3D8 antibody has also been shown by inhibition studies to recognize a serum antigen; this serum antigen is present in reduced amount in serum from In(Lu) donors. The present study demonstrates that the serum antigen recognized by A3D8 antibody also resides on a protein similar in size to the protein present in erythrocyte membranes. Studies using chromatographically purified protein have further shown that this antigen shares many epitopes with that present in RBCs and is therefore likely to be extremely homologous or identical to the erythrocyte In(Lu)-related p80.

Full Text

Duke Authors

Cited Authors

  • Lucas, MG; Green, AM; Telen, MJ

Published Date

  • February 1989

Published In

Volume / Issue

  • 73 / 2

Start / End Page

  • 596 - 600

PubMed ID

  • 2917192

Pubmed Central ID

  • 2917192

International Standard Serial Number (ISSN)

  • 0006-4971


  • eng

Conference Location

  • United States