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Human red cell antigens. IV. The abnormal sialoglycoprotein of Gerbich-negative red cells.

Publication ,  Journal Article
Telen, MJ; Bolk, TA
Published in: Transfusion
1987

The minor red cell sialoglycoproteins--beta and gamma (also known as glycophorin C)--are believed to be important to the structural integrity of red cells. The absence of sialoglycoproteins alpha and delta, as seen in En(a-) and S-s-U- cells, respectively, results in cells with normal morphology, but the absence of sialoglycoproteins beta and gamma is associated with elliptocytosis. However, cells that lack Gerbich (Ge) antigens but have an abnormal sialoglycoprotein reactive with antibodies to beta have normal morphology. The authors used a monoclonal antibody specific for beta to explore the nature of this abnormal sialoglycoprotein and its interactions with other membrane proteins. The beta-like sialoglycoprotein of Ge-Yus- red cells appears to react poorly with some antibodies due to steric hindrance by other molecules of sites normally available to immune agglutinins. This steric hindrance is not due to a single interaction with either sialoglycoprotein alpha or delta or band 3. Furthermore, steric hindrance by other molecules does not account for the lack of Ge antigens on these cells.

Duke Scholars

Published In

Transfusion

DOI

ISSN

0041-1132

Publication Date

1987

Volume

27

Issue

4

Start / End Page

309 / 314

Location

United States

Related Subject Headings

  • Sialoglycoproteins
  • Phenotype
  • Paper
  • Isoantigens
  • Humans
  • Erythrocytes
  • Electrophoresis, Polyacrylamide Gel
  • Collodion
  • Cardiovascular System & Hematology
  • Blood Group Antigens
 

Citation

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Telen, M. J., & Bolk, T. A. (1987). Human red cell antigens. IV. The abnormal sialoglycoprotein of Gerbich-negative red cells. Transfusion, 27(4), 309–314. https://doi.org/10.1046/j.1537-2995.1987.27487264736.x
Telen, M. J., and T. A. Bolk. “Human red cell antigens. IV. The abnormal sialoglycoprotein of Gerbich-negative red cells.Transfusion 27, no. 4 (1987): 309–14. https://doi.org/10.1046/j.1537-2995.1987.27487264736.x.
Telen, M. J., and T. A. Bolk. “Human red cell antigens. IV. The abnormal sialoglycoprotein of Gerbich-negative red cells.Transfusion, vol. 27, no. 4, 1987, pp. 309–14. Pubmed, doi:10.1046/j.1537-2995.1987.27487264736.x.
Journal cover image

Published In

Transfusion

DOI

ISSN

0041-1132

Publication Date

1987

Volume

27

Issue

4

Start / End Page

309 / 314

Location

United States

Related Subject Headings

  • Sialoglycoproteins
  • Phenotype
  • Paper
  • Isoantigens
  • Humans
  • Erythrocytes
  • Electrophoresis, Polyacrylamide Gel
  • Collodion
  • Cardiovascular System & Hematology
  • Blood Group Antigens