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LW protein: a promiscuous integrin receptor activated by adrenergic signaling.

Publication ,  Journal Article
Delahunty, M; Zennadi, R; Telen, MJ
Published in: Transfus Clin Biol
2006

The LW blood group antigen glycoprotein, although part of the Rh macromolecular complex, is nonetheless a member of the intercellular adhesion molecule (ICAM) family. Thus, while it is only rarely clinically important in the setting of transfusion and pregnancy, LW is likely to contribute to red cell adhesion in a variety of settings, including during hematopoiesis, as well as in vascular disorders. The best documentation of a pathophysiological role for LW in human disease is in sickle cell disease, where it contributes to red cell adhesion to endothelial cells and the development of vaso-occlusion, the hallmark of that disease. LW may also contribute to other intravascular processes, such as both venous and arterial thrombosis, due to its ability to interact with both activated platelets as well as leukocytes. The evidence that LW itself can undergo activation on red cells holds promise that pharmacotherapeutic maneuvers may be found to prevent such pathophysiologic interactions.

Duke Scholars

Published In

Transfus Clin Biol

DOI

ISSN

1246-7820

Publication Date

2006

Volume

13

Issue

1-2

Start / End Page

44 / 49

Location

France

Related Subject Headings

  • Thrombosis
  • Signal Transduction
  • Rh-Hr Blood-Group System
  • Receptors, Adrenergic, beta
  • Protein Processing, Post-Translational
  • Polymorphism, Single Nucleotide
  • Platelet Glycoprotein GPIIb-IIIa Complex
  • Phosphorylation
  • Lymphocyte Function-Associated Antigen-1
  • Integrin alphaV
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Delahunty, M., Zennadi, R., & Telen, M. J. (2006). LW protein: a promiscuous integrin receptor activated by adrenergic signaling. Transfus Clin Biol, 13(1–2), 44–49. https://doi.org/10.1016/j.tracli.2006.02.022
Delahunty, M., R. Zennadi, and M. J. Telen. “LW protein: a promiscuous integrin receptor activated by adrenergic signaling.Transfus Clin Biol 13, no. 1–2 (2006): 44–49. https://doi.org/10.1016/j.tracli.2006.02.022.
Delahunty M, Zennadi R, Telen MJ. LW protein: a promiscuous integrin receptor activated by adrenergic signaling. Transfus Clin Biol. 2006;13(1–2):44–9.
Delahunty, M., et al. “LW protein: a promiscuous integrin receptor activated by adrenergic signaling.Transfus Clin Biol, vol. 13, no. 1–2, 2006, pp. 44–49. Pubmed, doi:10.1016/j.tracli.2006.02.022.
Delahunty M, Zennadi R, Telen MJ. LW protein: a promiscuous integrin receptor activated by adrenergic signaling. Transfus Clin Biol. 2006;13(1–2):44–49.
Journal cover image

Published In

Transfus Clin Biol

DOI

ISSN

1246-7820

Publication Date

2006

Volume

13

Issue

1-2

Start / End Page

44 / 49

Location

France

Related Subject Headings

  • Thrombosis
  • Signal Transduction
  • Rh-Hr Blood-Group System
  • Receptors, Adrenergic, beta
  • Protein Processing, Post-Translational
  • Polymorphism, Single Nucleotide
  • Platelet Glycoprotein GPIIb-IIIa Complex
  • Phosphorylation
  • Lymphocyte Function-Associated Antigen-1
  • Integrin alphaV