Human erythrocyte acetylcholinesterase bears the Yta blood group antigen and is reduced or absent in the Yt(a-b-) phenotype.
The Cartwright (Yt) blood group antigens have previously been shown likely to reside on a phosphatidylinositol-linked erythrocyte membrane protein. In this study, an unusual individual whose red blood cells (RBCs) were of the previously unreported Yt(a-b-) phenotype were used, along with normal Yt(a+) cells, to investigate serologically and biochemically the relationship of the Yta antigen to known phosphatidylinositol-linked erythrocyte proteins. Yt(a-b-) RBCs expressed normal amounts of various phosphatidyl-inositol-linked proteins except acetylcholinesterase. Further, human anti-Yta reacted with acetylcholinesterase in immunoprecipitation and immunoblotting studies. Thus, acetylcholinesterase is now identified as the protein bearing the Yt blood group antigens.
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Related Subject Headings
- Radioimmunoassay
- Phenotype
- Molecular Weight
- Immunology
- Humans
- Erythrocytes
- Blood Group Antigens
- Antibodies, Monoclonal
- Acetylcholinesterase
- 3213 Paediatrics
Citation
Published In
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Radioimmunoassay
- Phenotype
- Molecular Weight
- Immunology
- Humans
- Erythrocytes
- Blood Group Antigens
- Antibodies, Monoclonal
- Acetylcholinesterase
- 3213 Paediatrics