Human erythrocyte acetylcholinesterase bears the Yta blood group antigen and is reduced or absent in the Yt(a-b-) phenotype.

Journal Article (Journal Article)

The Cartwright (Yt) blood group antigens have previously been shown likely to reside on a phosphatidylinositol-linked erythrocyte membrane protein. In this study, an unusual individual whose red blood cells (RBCs) were of the previously unreported Yt(a-b-) phenotype were used, along with normal Yt(a+) cells, to investigate serologically and biochemically the relationship of the Yta antigen to known phosphatidylinositol-linked erythrocyte proteins. Yt(a-b-) RBCs expressed normal amounts of various phosphatidyl-inositol-linked proteins except acetylcholinesterase. Further, human anti-Yta reacted with acetylcholinesterase in immunoprecipitation and immunoblotting studies. Thus, acetylcholinesterase is now identified as the protein bearing the Yt blood group antigens.

Full Text

Duke Authors

Cited Authors

  • Rao, N; Whitsett, CF; Oxendine, SM; Telen, MJ

Published Date

  • February 1, 1993

Published In

Volume / Issue

  • 81 / 3

Start / End Page

  • 815 - 819

PubMed ID

  • 8427972

International Standard Serial Number (ISSN)

  • 0006-4971


  • eng

Conference Location

  • United States