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Evidence that several high-frequency human blood group antigens reside on phosphatidylinositol-linked erythrocyte membrane proteins.

Publication ,  Journal Article
Telen, MJ; Rosse, WF; Parker, CJ; Moulds, MK; Moulds, JJ
Published in: Blood
April 1, 1990

Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired disorder associated with absence of expression of phosphatidylinositol (PI)-linked membrane proteins from circulating hematopoietic cells of multiple lineages. Recent work demonstrated that decay accelerating factor, one such PI-linked protein, bears the Cromer-related blood group antigens. This study demonstrated that other high incidence antigens, including Cartwright (Yta/Ytb), Holley-Gregory (Hy/Gya), John Milton Hagen (JMH), and Dombrock (Doa/Dob), are absent from the complement-sensitive (PNH III) erythrocytes of patients with PNH. The relatively normal, complement-insensitive erythrocytes from the same patients express these antigens normally. Therefore, these antigens most likely reside on PI-linked proteins absent from PNH III, but not PNH I, erythrocytes.

Duke Scholars

Published In

Blood

ISSN

0006-4971

Publication Date

April 1, 1990

Volume

75

Issue

7

Start / End Page

1404 / 1407

Location

United States

Related Subject Headings

  • Reference Values
  • Phosphatidylinositols
  • Membrane Proteins
  • Membrane Lipids
  • Immunology
  • Humans
  • Hemoglobinuria, Paroxysmal
  • Erythrocyte Membrane
  • Blood Group Antigens
  • Antibodies, Monoclonal
 

Citation

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Telen, M. J., Rosse, W. F., Parker, C. J., Moulds, M. K., & Moulds, J. J. (1990). Evidence that several high-frequency human blood group antigens reside on phosphatidylinositol-linked erythrocyte membrane proteins. Blood, 75(7), 1404–1407.
Telen, M. J., W. F. Rosse, C. J. Parker, M. K. Moulds, and J. J. Moulds. “Evidence that several high-frequency human blood group antigens reside on phosphatidylinositol-linked erythrocyte membrane proteins.Blood 75, no. 7 (April 1, 1990): 1404–7.
Telen MJ, Rosse WF, Parker CJ, Moulds MK, Moulds JJ. Evidence that several high-frequency human blood group antigens reside on phosphatidylinositol-linked erythrocyte membrane proteins. Blood. 1990 Apr 1;75(7):1404–1407.

Published In

Blood

ISSN

0006-4971

Publication Date

April 1, 1990

Volume

75

Issue

7

Start / End Page

1404 / 1407

Location

United States

Related Subject Headings

  • Reference Values
  • Phosphatidylinositols
  • Membrane Proteins
  • Membrane Lipids
  • Immunology
  • Humans
  • Hemoglobinuria, Paroxysmal
  • Erythrocyte Membrane
  • Blood Group Antigens
  • Antibodies, Monoclonal