Marked enhancement in myocardial function resulting from overexpression of a human beta-adrenergic receptor gene.
Journal Article (Journal Article)
Transgenic mice with intense cardiac expression of a human beta-adrenergic receptor gene were engineered and shown to display marked improvements in baseline myocardial and left ventricular function. Heart/body weight ratios and histologic appearance were not found to be significantly altered, suggesting that receptor gene expression did not induce pathologic changes. Given the substantial reduction in beta-adrenergic receptor density and resultant reduction in inotropic responsiveness observed in chronic heart failure, these findings represent a novel approach for increasing myocardial function with important clinical implications.
Full Text
Duke Authors
Cited Authors
- Milano, CA; Allen, LF; Dolber, PC; Johnson, TD; Rockman, HA; Bond, RA; Lefkowitz, RJ
Published Date
- February 1995
Published In
Volume / Issue
- 109 / 2
Start / End Page
- 236 - 241
PubMed ID
- 7853876
International Standard Serial Number (ISSN)
- 0022-5223
Digital Object Identifier (DOI)
- 10.1016/s0022-5223(95)70384-5
Language
- eng
Conference Location
- United States