Marked enhancement in myocardial function resulting from overexpression of a human beta-adrenergic receptor gene.

Journal Article (Journal Article)

Transgenic mice with intense cardiac expression of a human beta-adrenergic receptor gene were engineered and shown to display marked improvements in baseline myocardial and left ventricular function. Heart/body weight ratios and histologic appearance were not found to be significantly altered, suggesting that receptor gene expression did not induce pathologic changes. Given the substantial reduction in beta-adrenergic receptor density and resultant reduction in inotropic responsiveness observed in chronic heart failure, these findings represent a novel approach for increasing myocardial function with important clinical implications.

Full Text

Duke Authors

Cited Authors

  • Milano, CA; Allen, LF; Dolber, PC; Johnson, TD; Rockman, HA; Bond, RA; Lefkowitz, RJ

Published Date

  • February 1995

Published In

Volume / Issue

  • 109 / 2

Start / End Page

  • 236 - 241

PubMed ID

  • 7853876

International Standard Serial Number (ISSN)

  • 0022-5223

Digital Object Identifier (DOI)

  • 10.1016/s0022-5223(95)70384-5

Language

  • eng

Conference Location

  • United States