Skip to main content

Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation.

Publication ,  Journal Article
Iaccarino, G; Dolber, PC; Lefkowitz, RJ; Koch, WJ
Published in: Hypertension
January 1999

Pressure overload ventricular hypertrophy is accompanied by dysfunctional beta-adrenergic receptor signaling due to increased levels of the beta-adrenergic receptor kinase-1, which phosphorylates and desensitizes beta-adrenergic receptors. In this study, we examined whether increased beta-adrenergic receptor kinase 1 expression is associated with myocardial hypertrophy induced by adrenergic stimulation. With use of implanted mini-osmotic pumps, we treated mice with isoproterenol, phenylephrine, or vehicle to distinguish between alpha1- and beta-adrenergic stimulation. Both treatments resulted in cardiac hypertrophy, but only isoproterenol induced significant increases in beta-adrenergic receptor kinase-1 protein levels and activity. Similarly, in isolated adult rat cardiac myocytes, 24 hours of isoproterenol stimulation resulted in a significant 2.8-fold increase in beta-adrenergic receptor kinase-1 protein levels, whereas 24 hours of phenylephrine treatment did not alter beta-adrenergic receptor kinase-1 expression. Our results indicate that increased beta-adrenergic receptor kinase-1 is not invariably associated with myocardial hypertrophy but apparently is controlled by the state of beta-adrenergic receptor activation.

Duke Scholars

Published In

Hypertension

DOI

ISSN

0194-911X

Publication Date

January 1999

Volume

33

Issue

1 Pt 2

Start / End Page

396 / 401

Location

United States

Related Subject Headings

  • beta-Adrenergic Receptor Kinases
  • Signal Transduction
  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic, alpha-1
  • Rats, Sprague-Dawley
  • Rats
  • Radioligand Assay
  • Phenylephrine
  • Organ Size
  • Myocardium
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Iaccarino, G., Dolber, P. C., Lefkowitz, R. J., & Koch, W. J. (1999). Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation. Hypertension, 33(1 Pt 2), 396–401. https://doi.org/10.1161/01.hyp.33.1.396
Iaccarino, G., P. C. Dolber, R. J. Lefkowitz, and W. J. Koch. “Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation.Hypertension 33, no. 1 Pt 2 (January 1999): 396–401. https://doi.org/10.1161/01.hyp.33.1.396.
Iaccarino, G., et al. “Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation.Hypertension, vol. 33, no. 1 Pt 2, Jan. 1999, pp. 396–401. Pubmed, doi:10.1161/01.hyp.33.1.396.

Published In

Hypertension

DOI

ISSN

0194-911X

Publication Date

January 1999

Volume

33

Issue

1 Pt 2

Start / End Page

396 / 401

Location

United States

Related Subject Headings

  • beta-Adrenergic Receptor Kinases
  • Signal Transduction
  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic, alpha-1
  • Rats, Sprague-Dawley
  • Rats
  • Radioligand Assay
  • Phenylephrine
  • Organ Size
  • Myocardium