Effect of isocaloric low-fat diet on prostate cancer xenograft progression to androgen independence.


Journal Article

An isocaloric low-fat diet has been shown to slow androgen-sensitive Los Angeles Prostate Cancer-4 (LAPC-4) tumor growth in a mouse xenograft model. LAPC-4 cells were injected into male severe combined immunodeficient mice. After palpable tumors developed, the mice were divided into three groups, high-fat intact, high-fat castration, and low-fat castration. Tumor latency (18 versus 9 weeks; P < 0.001) and mouse survival (20.8 +/- 1.3 versus 13 +/- 0.7 weeks; P < 0.01) were significantly longer in the low-fat castration versus high-fat castration group. Reduced dietary fat intake delayed conversion from androgen-sensitive to -insensitive prostate cancer and significantly prolonged survival of severe combined immunodeficient mice bearing LAPC-4 xenografts.

Full Text

Cited Authors

  • Ngo, TH; Barnard, RJ; Anton, T; Tran, C; Elashoff, D; Heber, D; Freedland, SJ; Aronson, WJ

Published Date

  • February 2004

Published In

Volume / Issue

  • 64 / 4

Start / End Page

  • 1252 - 1254

PubMed ID

  • 14973081

Pubmed Central ID

  • 14973081

Electronic International Standard Serial Number (EISSN)

  • 1538-7445

International Standard Serial Number (ISSN)

  • 0008-5472

Digital Object Identifier (DOI)

  • 10.1158/0008-5472.can-03-3830


  • eng