Effect of isocaloric low-fat diet on prostate cancer xenograft progression to androgen independence.
Published
Journal Article
An isocaloric low-fat diet has been shown to slow androgen-sensitive Los Angeles Prostate Cancer-4 (LAPC-4) tumor growth in a mouse xenograft model. LAPC-4 cells were injected into male severe combined immunodeficient mice. After palpable tumors developed, the mice were divided into three groups, high-fat intact, high-fat castration, and low-fat castration. Tumor latency (18 versus 9 weeks; P < 0.001) and mouse survival (20.8 +/- 1.3 versus 13 +/- 0.7 weeks; P < 0.01) were significantly longer in the low-fat castration versus high-fat castration group. Reduced dietary fat intake delayed conversion from androgen-sensitive to -insensitive prostate cancer and significantly prolonged survival of severe combined immunodeficient mice bearing LAPC-4 xenografts.
Full Text
Cited Authors
- Ngo, TH; Barnard, RJ; Anton, T; Tran, C; Elashoff, D; Heber, D; Freedland, SJ; Aronson, WJ
Published Date
- February 2004
Published In
Volume / Issue
- 64 / 4
Start / End Page
- 1252 - 1254
PubMed ID
- 14973081
Pubmed Central ID
- 14973081
Electronic International Standard Serial Number (EISSN)
- 1538-7445
International Standard Serial Number (ISSN)
- 0008-5472
Digital Object Identifier (DOI)
- 10.1158/0008-5472.can-03-3830
Language
- eng