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Treatment of digitalis intoxication with emphasis on the clinical use of digoxin immune Fab.

Publication ,  Journal Article
Allen, NM; Dunham, GD
Published in: DICP
October 1990

Many studies and cases of digitalis intoxication have been reported since the time of William Withering's first publication in 1785. Recognition and management of digitalis toxicity is challenging. Before digoxin immune Fab was commercially available, treatment consisted of managing the signs and symptoms of toxicity until the digitalis was eliminated. Digoxin immune Fab offers a safe, effective, and specific method of quickly reversing digitalis toxicity. Factors that must be considered with the clinical use of this agent include the dosage calculation, administration technique, postdose monitoring, pharmacokinetics, mechanism of action, interference with commercially available digoxin assays, partial neutralizing dosing, rebound of free digoxin, and indications for use. For severe, life-threatening toxicity, digoxin immune Fab is the treatment of choice.

Duke Scholars

Published In

DICP

DOI

ISSN

1042-9611

Publication Date

October 1990

Volume

24

Issue

10

Start / End Page

991 / 998

Location

United States

Related Subject Headings

  • Poisoning
  • Immunoglobulin Fab Fragments
  • Humans
  • Digitalis Glycosides
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Allen, N. M., & Dunham, G. D. (1990). Treatment of digitalis intoxication with emphasis on the clinical use of digoxin immune Fab. DICP, 24(10), 991–998. https://doi.org/10.1177/106002809002401015
Allen, N. M., and G. D. Dunham. “Treatment of digitalis intoxication with emphasis on the clinical use of digoxin immune Fab.DICP 24, no. 10 (October 1990): 991–98. https://doi.org/10.1177/106002809002401015.
Allen, N. M., and G. D. Dunham. “Treatment of digitalis intoxication with emphasis on the clinical use of digoxin immune Fab.DICP, vol. 24, no. 10, Oct. 1990, pp. 991–98. Pubmed, doi:10.1177/106002809002401015.

Published In

DICP

DOI

ISSN

1042-9611

Publication Date

October 1990

Volume

24

Issue

10

Start / End Page

991 / 998

Location

United States

Related Subject Headings

  • Poisoning
  • Immunoglobulin Fab Fragments
  • Humans
  • Digitalis Glycosides
  • Animals