DNA in radical prostatectomy specimens. Prognostic value of tumor ploidy.

Journal Article (Journal Article)

In a series of 94 patients with prostatic adenocarcinoma the prognostic significance of some factors was studied after radical prostatectomy. DNA ploidy was assessed by flow cytometry of cells from deparaffinized specimens. Gleason sum, seminal vesicle status and ploidy turned all out to be important predictors of disease progression. The ploidy status significantly enhanced the ability to prognostically evaluate patients with intermediate grade carcinoma compared to tumor grade alone. Patients with seminal vesicle invasion and aneuploidy had a very poor prognosis which prompts trials with alternatives of adjuvant therapy in this patient population.

Full Text

Duke Authors

Cited Authors

  • Robertson, CN; Paulson, DF

Published Date

  • 1991

Published In

Volume / Issue

  • 30 / 2

Start / End Page

  • 205 - 207

PubMed ID

  • 2029406

International Standard Serial Number (ISSN)

  • 0284-186X

Digital Object Identifier (DOI)

  • 10.3109/02841869109092351


  • eng

Conference Location

  • England