Differential immunoreactivity of her-2/neu oncoprotein in prostatic tissues.

Journal Article (Journal Article)

To investigate HER-2/neu oncoprotein immunoreactivity, monoclonal antibody TA1 immunohistochemical examination of flash-frozen radical prostatectomy specimens was performed (n = 35). All prostatic specimens contained benign prostatic hyperplasia (BPH) and/or prostatic intraepithelial neoplasia (PIN), as well as prostatic carcinoma (CaP). HER-2/neu oncoprotein immunoreactivity in BPH tissues was not significantly different than that for the PIN basal cell layer (P = 0.10) or for the PIN luminal cells (P = 0.17). There was significantly more HER-2/neu oncoprotein immunoreactivity in BPH than in areas of CaP (P < 0.001). There was no significant difference in the amount of immunoreactivity present in PIN basal cells when compared to the PIN luminal cells (P = 0.49). Both the PIN basal cells and luminal cells stained for the HER-2/neu oncoprotein to a higher degree than cells in the CaP areas (P < 0.001 in both cases). HER-2/neu oncoprotein immunoreactivity is present at a significantly higher degree in BPH and PIN than in malignant prostatic epithelium.

Full Text

Duke Authors

Cited Authors

  • Ibrahim, GK; MacDonald, JA; Kerns, BJ; Ibrahim, SN; Humphrey, PA; Robertson, CN

Published Date

  • April 1992

Published In

Volume / Issue

  • 1 / 2

Start / End Page

  • 151 - 155

PubMed ID

  • 1285216

International Standard Serial Number (ISSN)

  • 0960-7404

Digital Object Identifier (DOI)

  • 10.1016/0960-7404(92)90028-j


  • eng

Conference Location

  • Netherlands