Synthesis and characterization of copper(II) complexes of cysteinyldopa and benzothiazine model ligands related to pheomelanin.
Journal Article
A new cysteinyldopa model ligand Cydo {3-[(2-aminoethyl)sulfanyl]-4,6-di-tert-butylbenzene-1,2-diol} was prepared and its reactivity with Cu(II) explored. Under anaerobic conditions, tetranuclear [Cu4(Cydo)4] is isolated, but in the presence of O2, a benzothiazine intermediate accumulates that is trapped as the Cu(II) complex [Cu(zine)2]. Under slightly different reaction conditions, the benzothiazine further oxidizes to benzothiazole (zole). All three compounds were characterized by X-ray crystallography, and the reactions were monitored spectrophotometrically.
Full Text
Duke Authors
Cited Authors
- Tesema, YT; Pham, DM; Franz, KJ
Published Date
- August 2006
Published In
Volume / Issue
- 45 / 16
Start / End Page
- 6102 - 6104
PubMed ID
- 16878910
Pubmed Central ID
- 16878910
Electronic International Standard Serial Number (EISSN)
- 1520-510X
International Standard Serial Number (ISSN)
- 0020-1669
Digital Object Identifier (DOI)
- 10.1021/ic060262n
Language
- eng