Synthesis and characterization of copper(II) complexes of cysteinyldopa and benzothiazine model ligands related to pheomelanin.

Journal Article (Journal Article)

A new cysteinyldopa model ligand Cydo {3-[(2-aminoethyl)sulfanyl]-4,6-di-tert-butylbenzene-1,2-diol} was prepared and its reactivity with Cu(II) explored. Under anaerobic conditions, tetranuclear [Cu4(Cydo)4] is isolated, but in the presence of O2, a benzothiazine intermediate accumulates that is trapped as the Cu(II) complex [Cu(zine)2]. Under slightly different reaction conditions, the benzothiazine further oxidizes to benzothiazole (zole). All three compounds were characterized by X-ray crystallography, and the reactions were monitored spectrophotometrically.

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Published version (via Digital Object Identifier)

Duke Authors

Franz, Katherine J.

Cited Authors

Tesema, YT; Pham, DM; Franz, KJ

Published Date

August 2006

Published In

Inorganic Chemistry

Volume / Issue

45 / 16

Start / End Page

6102 - 6104

PubMed ID

16878910

Electronic International Standard Serial Number (EISSN)

1520-510X

International Standard Serial Number (ISSN)

0020-1669

Digital Object Identifier (DOI)

10.1021/ic060262n

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