Regulation of leukocyte migration by activation of the leukocyte adhesion molecule-1 (LAM-1) selectin.

Journal Article (Journal Article)

A central feature of host defence is the ability of leukocytes to enter tissues in response to immune or inflammatory stimuli. The leukocyte adhesion molecule-1 (LAM-1) regulates the migration of human leukocytes by mediating the binding both of lymphocytes to high endothelial venules of peripheral lymph nodes and of neutrophils to endothelium at inflammatory sites. As lymphocytes and neutrophils express the same LAM-1 protein, it is not clear how lineage-specific differences in leukocyte migration are controlled. We now report that the affinity of LAM-1 for a carbohydrate-based ligand, PPME, is dramatically increased following lymphocyte and neutrophil activation by lineage-specific stimuli. In addition, activation of lymphocytes by physiological stimuli enhanced LAM-1-dependent binding to high endothelial venules. Thus, transient changes in LAM-1 affinity after leukocyte stimulation probably directly influence leukocyte migration.

Full Text

Duke Authors

Cited Authors

  • Spertini, O; Kansas, GS; Munro, JM; Griffin, JD; Tedder, TF

Published Date

  • February 21, 1991

Published In

Volume / Issue

  • 349 / 6311

Start / End Page

  • 691 - 694

PubMed ID

  • 1705015

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/349691a0


  • eng

Conference Location

  • England