Human epithelial cell expression of an Epstein-Barr virus receptor.

Journal Article (Journal Article)

Cultured human epithelium bound and internalized radiolabelled Epstein-Barr virus (EBV) within 1 h of exposure. A similar percentage of cultured cells also were reactive with monoclonal antibodies to the EBV/C3d receptor of B lymphocytes. In cross-sections of fresh frozen, stratified epithelium, receptor expression seemed limited to the less differentiated subpopulation of cells. These findings support the notion of direct infection of epithelial cells by EBV and suggest a viral life cycle in epithelium dependent on the stage of cell differentiation.

Full Text

Duke Authors

Cited Authors

  • Sixbey, JW; Davis, DS; Young, LS; Hutt-Fletcher, L; Tedder, TF; Rickinson, AB

Published Date

  • March 1, 1987

Published In

Volume / Issue

  • 68 ( Pt 3) /

Start / End Page

  • 805 - 811

PubMed ID

  • 3029307

International Standard Serial Number (ISSN)

  • 0022-1317

Digital Object Identifier (DOI)

  • 10.1099/0022-1317-68-3-805


  • eng

Conference Location

  • England