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Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule.

Publication ,  Journal Article
Engel, P; Zhou, LJ; Ord, DC; Sato, S; Koller, B; Tedder, TF
Published in: Immunity
July 1995

CD19-deficient mice were generated to examine the role of CD19 in B cell growth regulation in vivo. Deletion of CD19 had no deleterious effects on the generation of B cells in the bone marrow, but there was a significant reduction in the number of B cells in peripheral lymphoid tissues. B cells from CD19-deficient mice exhibited markedly decreased proliferative responses to mitogens, and serum immunoglobulin levels were also significantly decreased. In contrast, mice that overexpressed CD19 had significant defects in early B cell development in the bone marrow, augmented mitogenic responses, and increased serum immunoglobulin levels. These experiments indicate that CD19 functions to define signaling thresholds for cell surface receptors that regulate B lymphocyte selection, activation, and differentiation.

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Published In

Immunity

DOI

EISSN

1097-4180

ISSN

1074-7613

Publication Date

July 1995

Volume

3

Issue

1

Start / End Page

39 / 50

Related Subject Headings

  • Spleen
  • Signal Transduction
  • Mice, Mutant Strains
  • Mice
  • Lymphocyte Activation
  • Immunology
  • Immunoglobulins
  • Gene Deletion
  • Cell Division
  • Cell Differentiation
 

Citation

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ICMJE
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Engel, P., Zhou, L. J., Ord, D. C., Sato, S., Koller, B., & Tedder, T. F. (1995). Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule. Immunity, 3(1), 39–50. https://doi.org/10.1016/1074-7613(95)90157-4
Engel, P., L. J. Zhou, D. C. Ord, S. Sato, B. Koller, and T. F. Tedder. “Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule.Immunity 3, no. 1 (July 1995): 39–50. https://doi.org/10.1016/1074-7613(95)90157-4.
Engel, P., et al. “Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule.Immunity, vol. 3, no. 1, July 1995, pp. 39–50. Epmc, doi:10.1016/1074-7613(95)90157-4.
Journal cover image

Published In

Immunity

DOI

EISSN

1097-4180

ISSN

1074-7613

Publication Date

July 1995

Volume

3

Issue

1

Start / End Page

39 / 50

Related Subject Headings

  • Spleen
  • Signal Transduction
  • Mice, Mutant Strains
  • Mice
  • Lymphocyte Activation
  • Immunology
  • Immunoglobulins
  • Gene Deletion
  • Cell Division
  • Cell Differentiation