Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule.

Published

Journal Article

CD19-deficient mice were generated to examine the role of CD19 in B cell growth regulation in vivo. Deletion of CD19 had no deleterious effects on the generation of B cells in the bone marrow, but there was a significant reduction in the number of B cells in peripheral lymphoid tissues. B cells from CD19-deficient mice exhibited markedly decreased proliferative responses to mitogens, and serum immunoglobulin levels were also significantly decreased. In contrast, mice that overexpressed CD19 had significant defects in early B cell development in the bone marrow, augmented mitogenic responses, and increased serum immunoglobulin levels. These experiments indicate that CD19 functions to define signaling thresholds for cell surface receptors that regulate B lymphocyte selection, activation, and differentiation.

Full Text

Duke Authors

Cited Authors

  • Engel, P; Zhou, LJ; Ord, DC; Sato, S; Koller, B; Tedder, TF

Published Date

  • July 1995

Published In

Volume / Issue

  • 3 / 1

Start / End Page

  • 39 - 50

PubMed ID

  • 7542548

Pubmed Central ID

  • 7542548

International Standard Serial Number (ISSN)

  • 1074-7613

Digital Object Identifier (DOI)

  • 10.1016/1074-7613(95)90157-4

Language

  • eng

Conference Location

  • United States