New CD from the B cell section of the Fifth International Workshop on Human Leukocyte Differentiation Antigens.

Published

Journal Article (Review)

This review summaries the expression and the molecular and biochemical characteristics of eight new Clusters of Differentiation (CD79-CD86) established by the B cell Section during the Fifth International Workshop on Human Leukocyte Differentiation Antigens. CD79 monoclonal antibodies (mAb) identify the mbl (CD79 alpha) and B29 (CD79 beta) components of the surface immunoglobulin (Ig) receptor complex. CD80 (B7/BB-1) is a costimulatory molecule that serves as the ligand for two molecules expressed on T lymphocytes, CD28 and CTLA-4. CD81 (TAPA-1) and CD82 (R2) are new members of the tetra-spans family of transmembrane proteins, which include CD9, CD37, CD53 and CD63. These proteins are postulated to be involved in signal transduction. CD83 (HB15) is a marker for human interdigitating reticulum cells, circulating dendritic cells and Langerhans cells. CDw84 and CD85 are new B cell-associated molecules that are also expressed by monocytes. CD86 is a new B cell activation antigen.

Full Text

Duke Authors

Cited Authors

  • Engel, P; Tedder, TF

Published Date

  • 1994

Published In

Volume / Issue

  • 13 Suppl 1 /

Start / End Page

  • 61 - 64

PubMed ID

  • 8075582

Pubmed Central ID

  • 8075582

International Standard Serial Number (ISSN)

  • 1042-8194

Digital Object Identifier (DOI)

  • 10.3109/10428199409052677

Language

  • eng

Conference Location

  • United States