Monocyte attachment to activated human vascular endothelium in vitro is mediated by leukocyte adhesion molecule-1 (L-selectin) under nonstatic conditions.

Journal Article (Journal Article)

The receptors that mediate monocyte adhesion to cytokine-stimulated endothelial monolayers were assessed using a nonstatic (rotating) cell-attachment assay. In this system, leukocyte adhesion molecule-1 (LAM-1) (L-selectin) mediated a major portion (87 +/- 15% at 37 degrees C) of monocyte attachment to activated endothelium. mAb blocking of endothelial leukocyte adhesion molecule-1 (41% inhibition), CD18 (36%), and vascular cell adhesion molecule-1 (25%) function had lesser effects on attachment. These results suggest that LAM-1 may serve an important role in monocyte attachment to endothelium at sites of inflammation.

Full Text

Duke Authors

Cited Authors

  • Spertini, O; Luscinskas, FW; Gimbrone, MA; Tedder, TF

Published Date

  • June 1, 1992

Published In

Volume / Issue

  • 175 / 6

Start / End Page

  • 1789 - 1792

PubMed ID

  • 1375271

Pubmed Central ID

  • PMC2119244

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.175.6.1789


  • eng

Conference Location

  • United States