Leukocyte interactions with vascular endothelium. New insights into selectin-mediated attachment and rolling.

Journal Article (Journal Article)

Among the earliest signs of inflammation is the capture of leukocytes from the blood stream and their subsequent rolling along the endothelium of postcapillary venules. This commentary summarizes recent insight into the molecular basis of leukocyte rolling gained from gene-targeted mice, Ab blocking studies, and in vitro and in vivo reconstitution assays. These data reveal how the selectins individually and collectively contribute to the process of leukocyte capture and subsequent rolling on vascular endothelium.

Full Text

Duke Authors

Cited Authors

  • Ley, K; Tedder, TF

Published Date

  • July 15, 1995

Published In

Volume / Issue

  • 155 / 2

Start / End Page

  • 525 - 528

PubMed ID

  • 7541818

International Standard Serial Number (ISSN)

  • 0022-1767


  • eng

Conference Location

  • United States