CD83 expression influences CD4+ T cell development in the thymus.

Published

Journal Article

T lymphocyte selection and lineage commitment in the thymus requires multiple signals. Herein, CD4+ T cell generation required engagement of CD83, a surface molecule expressed by thymic epithelial and dendritic cells. CD83-deficient (CD83-/-) mice had a specific block in CD4+ single-positive thymocyte development without increased CD4+CD8+ double- or CD8+ single-positive thymocytes. This resulted in a selective 75%-90% reduction in peripheral CD4+ T cells, predominantly within the naive subset. Wild-type thymocytes and bone marrow stem cells failed to differentiate into mature CD4+ T cells when transferred into CD83-/- mice, while CD83-/- thymocytes and stem cells developed normally in wild-type mice. Thereby, CD83 expression represents an additional regulatory component for CD4+ T cell development in the thymus.

Full Text

Duke Authors

Cited Authors

  • Fujimoto, Y; Tu, L; Miller, AS; Bock, C; Fujimoto, M; Doyle, C; Steeber, DA; Tedder, TF

Published Date

  • March 22, 2002

Published In

Volume / Issue

  • 108 / 6

Start / End Page

  • 755 - 767

PubMed ID

  • 11955430

Pubmed Central ID

  • 11955430

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/s0092-8674(02)00673-6

Language

  • eng

Conference Location

  • United States