CD22 negatively and positively regulates signal transduction through the B lymphocyte antigen receptor.

Journal Article (Journal Article;Review)

The CD22 cell-surface adhesion molecule is capable of modulating B lymphocyte antigen receptor (BCR)-mediated signals, as well as the generation of BCR-independent signals. Within the cytoplasmic domain of CD22 are motifs that are structurally homologous to known activation and inhibitory motifs. These motifs demonstrate physiologic significance via associations with known effector proteins that likely mediate their corresponding inhibitory and activation roles. Furthermore, the targeted deletion of CD22 in mice results in phenotypic changes and alterations in BCR-mediated signal transduction that are consistent with both positive and negative roles for CD22 in B cell development and activation.

Full Text

Duke Authors

Cited Authors

  • Sato, S; Tuscano, JM; Inaoki, M; Tedder, TF

Published Date

  • August 1998

Published In

Volume / Issue

  • 10 / 4

Start / End Page

  • 287 - 297

PubMed ID

  • 9695185

International Standard Serial Number (ISSN)

  • 1044-5323

Digital Object Identifier (DOI)

  • 10.1006/smim.1998.0121


  • eng

Conference Location

  • England