Function of the LFA-1 and T4 molecules in the direct activation of resting human B lymphocytes by T lymphocytes.

Journal Article

Activated T lymphocytes can provide all of the signals necessary to induce the proliferation of resting B lymphocytes. The activation signal is presumably initiated through direct T-B lymphocyte contact. The role of the leukocyte function antigen-1 (LFA-1) and T4 molecules in the activation of purified, small B lymphocytes by mitomycin C-treated T lymphocytes was examined by using monoclonal antibodies that react with and inhibit the function of these molecules. Anti-LFA-1 antibody binding significantly inhibited T-B lymphocyte interactions that result in B lymphocyte proliferation. In contrast, the presence of anti-T4 antibodies at concentrations as high as 100 micrograms/ml did not inhibit this interaction. These results indicate that the B lymphocyte activation signal may not be mediated through the interaction of T4 molecules with major histocompatibility complex class II antigens of the B lymphocyte but is a cell-cell contact-dependent event that is facilitated by LFA-1 molecules.

Full Text

Duke Authors

Cited Authors

  • Tedder, TF; Schmidt, RE; Rudd, CE; Kornacki, MM; Ritz, J; Schlossman, SF

Published Date

  • December 1986

Published In

Volume / Issue

  • 16 / 12

Start / End Page

  • 1539 - 1543

PubMed ID

  • 3102246

International Standard Serial Number (ISSN)

  • 0014-2980

Digital Object Identifier (DOI)

  • 10.1002/eji.1830161212

Language

  • eng

Conference Location

  • Germany