Function of the LFA-1 and T4 molecules in the direct activation of resting human B lymphocytes by T lymphocytes.
Journal Article (Journal Article)
Activated T lymphocytes can provide all of the signals necessary to induce the proliferation of resting B lymphocytes. The activation signal is presumably initiated through direct T-B lymphocyte contact. The role of the leukocyte function antigen-1 (LFA-1) and T4 molecules in the activation of purified, small B lymphocytes by mitomycin C-treated T lymphocytes was examined by using monoclonal antibodies that react with and inhibit the function of these molecules. Anti-LFA-1 antibody binding significantly inhibited T-B lymphocyte interactions that result in B lymphocyte proliferation. In contrast, the presence of anti-T4 antibodies at concentrations as high as 100 micrograms/ml did not inhibit this interaction. These results indicate that the B lymphocyte activation signal may not be mediated through the interaction of T4 molecules with major histocompatibility complex class II antigens of the B lymphocyte but is a cell-cell contact-dependent event that is facilitated by LFA-1 molecules.
Full Text
Duke Authors
Cited Authors
- Tedder, TF; Schmidt, RE; Rudd, CE; Kornacki, MM; Ritz, J; Schlossman, SF
Published Date
- December 1986
Published In
Volume / Issue
- 16 / 12
Start / End Page
- 1539 - 1543
PubMed ID
- 3102246
International Standard Serial Number (ISSN)
- 0014-2980
Digital Object Identifier (DOI)
- 10.1002/eji.1830161212
Language
- eng
Conference Location
- Germany