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L-selectin and beta7 integrin synergistically mediate lymphocyte migration to mesenteric lymph nodes.

Publication ,  Journal Article
Wagner, N; Löhler, J; Tedder, TF; Rajewsky, K; Müller, W; Steeber, DA
Published in: European journal of immunology
November 1998

Mesenteric lymph nodes (MLN) drain the gut where nutritive antigens and pathogens are encountered by lymphocytes of the gut-associated lymphoid tissue. We sought to determine how lymphocytes enter the MLN by studying mice double deficient for beta7 integrins and L-selectin. beta7/L-selectin double-deficient lymphocytes did not migrate into MLN. Most importantly, MLN formation was drastically impaired in beta7/L-selectin double-deficient mice. Lymphocyte numbers in MLN from beta7/L-selectin double-deficient mice were tenfold reduced compared to control mice. A high percentage of the few lymphocytes still detected in MLN from beta7/L-selectin double-deficient mice were CD44hi CD18hi, suggesting alternate migration pathways independent of L-selectin and beta7 integrin for these cells. We conclude that the combination of both molecules, L-selectin and beta7 integrin, is indispensable for MLN formation and that these molecules may mediate lymphocyte migration to MLN in a sequential and synergistical manner.

Published In

European journal of immunology

DOI

EISSN

1521-4141

ISSN

0014-2980

Publication Date

November 1998

Volume

28

Issue

11

Start / End Page

3832 / 3839

Related Subject Headings

  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Mesentery
  • Lymphocytes
  • Lymph Nodes
  • L-Selectin
  • Integrins
  • Integrin beta Chains
  • Immunology
 

Citation

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Wagner, N., Löhler, J., Tedder, T. F., Rajewsky, K., Müller, W., & Steeber, D. A. (1998). L-selectin and beta7 integrin synergistically mediate lymphocyte migration to mesenteric lymph nodes. European Journal of Immunology, 28(11), 3832–3839. https://doi.org/10.1002/(sici)1521-4141(199811)28:11<3832::aid-immu3832>3.0.co;2-j
Wagner, N., J. Löhler, T. F. Tedder, K. Rajewsky, W. Müller, and D. A. Steeber. “L-selectin and beta7 integrin synergistically mediate lymphocyte migration to mesenteric lymph nodes.European Journal of Immunology 28, no. 11 (November 1998): 3832–39. https://doi.org/10.1002/(sici)1521-4141(199811)28:11<3832::aid-immu3832>3.0.co;2-j.
Wagner N, Löhler J, Tedder TF, Rajewsky K, Müller W, Steeber DA. L-selectin and beta7 integrin synergistically mediate lymphocyte migration to mesenteric lymph nodes. European journal of immunology. 1998 Nov;28(11):3832–9.
Wagner, N., et al. “L-selectin and beta7 integrin synergistically mediate lymphocyte migration to mesenteric lymph nodes.European Journal of Immunology, vol. 28, no. 11, Nov. 1998, pp. 3832–39. Epmc, doi:10.1002/(sici)1521-4141(199811)28:11<3832::aid-immu3832>3.0.co;2-j.
Wagner N, Löhler J, Tedder TF, Rajewsky K, Müller W, Steeber DA. L-selectin and beta7 integrin synergistically mediate lymphocyte migration to mesenteric lymph nodes. European journal of immunology. 1998 Nov;28(11):3832–3839.
Journal cover image

Published In

European journal of immunology

DOI

EISSN

1521-4141

ISSN

0014-2980

Publication Date

November 1998

Volume

28

Issue

11

Start / End Page

3832 / 3839

Related Subject Headings

  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Mesentery
  • Lymphocytes
  • Lymph Nodes
  • L-Selectin
  • Integrins
  • Integrin beta Chains
  • Immunology