A new twist to the leukocyte adhesion cascade: intimate cooperation is key.

Journal Article (Journal Article;Review)

Leukocyte migration from blood into lymphoid and non-lymphoid tissues requires a highly orchestrated series of adhesive and signaling events. A network of adhesion molecules with overlapping functions mediate the capture, rolling and firm adhesion of leukocytes to the vascular endothelium. A new study adds a novel twist to this paradigm by demonstrating that two adhesion molecules, CD44 and VLA-4, must be physically associated with each other on activated T cells to mediate efficient rolling and firm adhesion.

Full Text

Duke Authors

Cited Authors

  • Steeber, DA; Venturi, GM; Tedder, TF

Published Date

  • January 2005

Published In

Volume / Issue

  • 26 / 1

Start / End Page

  • 9 - 12

PubMed ID

  • 15629403

International Standard Serial Number (ISSN)

  • 1471-4906

Digital Object Identifier (DOI)

  • 10.1016/j.it.2004.11.012


  • eng

Conference Location

  • England