B lymphocytes contribute to autoimmune disease pathogenesis: current trends and clinical implications.

Journal Article (Journal Article;Review)

Abnormal B lymphocytes influence the pathogenesis of many autoimmune diseases, in addition to serving as the origin of pathogenic autoantibodies. Although aberrant B cell function and autoimmunity have complex polygenic origins, recent studies in mouse models of autoimmune diseases have revealed overlapping defects in signal transduction pathways that alter B cell survival or activation, and lead to an autoimmune phenotype. Discovery of these important signaling pathways in mice has lead to an intense search for B cell abnormalities that correlate with autoimmune diseases in humans. This search has identified potential targets for therapeutic intervention that are the focus of planned and ongoing human clinical trials. This promises an arsenal of highly targeted, less toxic therapies focused on restoring normal B cell function that will eliminate pathogenic autoantibodies and replace the current use of immunosuppressive drugs.

Full Text

Duke Authors

Cited Authors

  • Tuscano, JM; Harris, GS; Tedder, TF

Published Date

  • March 2003

Published In

Volume / Issue

  • 2 / 2

Start / End Page

  • 101 - 108

PubMed ID

  • 12848966

International Standard Serial Number (ISSN)

  • 1568-9972

Digital Object Identifier (DOI)

  • 10.1016/s1568-9972(02)00148-9


  • eng

Conference Location

  • Netherlands