Antifibrotic and uveitogenic properties of gamma interferon in the rabbit eye.

Journal Article (Journal Article)

The feasibility of gamma (gamma)-interferon injection for the treatment of ocular fibrotic conditions was studied in rabbits using recombinant rabbit gamma-interferon and the cell-injection model of tractional detachment. A toxicity study revealed that intravitreal injection of greater than 10(4) units gamma-interferon consistently produced panuveitis. For tractional detachment, 250,000 rabbit dermal fibroblasts were injected intravitreally into 20 eyes; 1 day later, 5 of these eyes received intravitreal injections of 10(4) units gamma-interferon, another 5 were given 10(6) units, and the remaining 10 received balanced salt solution. Slit-lamp examination and fundus photography were performed at regular intervals for 21 days and were graded by a masked observer. The eyes were then enucleated and processed for histology. Doses of 10(4) units gamma-interferon significantly reduced the severity of detachments, but injections of 10(6) units induced panuveitis.

Full Text

Duke Authors

Cited Authors

  • Hjelmeland, LM; Li, JW; Toth, CA; Landers, MB

Published Date

  • 1992

Published In

Volume / Issue

  • 230 / 1

Start / End Page

  • 84 - 90

PubMed ID

  • 1547974

International Standard Serial Number (ISSN)

  • 0721-832X

Digital Object Identifier (DOI)

  • 10.1007/BF00166768


  • eng

Conference Location

  • Germany