Glucocorticosteroid inhibition of intraocular proliferation after injury.

Journal Article (Journal Article)

Perforating injuries were produced in the posterior segment of rabbit eyes. We studied the inhibitory effect of a slowly water-soluble corticosteroid, dexamethasone alcohol, on fibroblast growth. The treated group received a single intravitreal injection of 1 mg of the corticosteroid. The eyes were observed for four weeks. Transvitreal proliferation was significantly decreased and wound healing was delayed as compared to a control group. Inhibition of intraocular proliferation by high doses of intravitreally injected corticosteroid may be useful in the treatment of eyes with penetrating and perforating injuries.

Full Text

Duke Authors

Cited Authors

  • Tano, Y; Chandler, DB; McCuen, BW; Machemer, R

Published Date

  • February 1, 1981

Published In

Volume / Issue

  • 91 / 2

Start / End Page

  • 184 - 189

PubMed ID

  • 7468732

International Standard Serial Number (ISSN)

  • 0002-9394

Digital Object Identifier (DOI)

  • 10.1016/0002-9394(81)90171-9


  • eng

Conference Location

  • United States