Glucocorticosteroid inhibition of intraocular proliferation after injury.
Journal Article (Journal Article)
Perforating injuries were produced in the posterior segment of rabbit eyes. We studied the inhibitory effect of a slowly water-soluble corticosteroid, dexamethasone alcohol, on fibroblast growth. The treated group received a single intravitreal injection of 1 mg of the corticosteroid. The eyes were observed for four weeks. Transvitreal proliferation was significantly decreased and wound healing was delayed as compared to a control group. Inhibition of intraocular proliferation by high doses of intravitreally injected corticosteroid may be useful in the treatment of eyes with penetrating and perforating injuries.
Full Text
Duke Authors
Cited Authors
- Tano, Y; Chandler, DB; McCuen, BW; Machemer, R
Published Date
- February 1, 1981
Published In
Volume / Issue
- 91 / 2
Start / End Page
- 184 - 189
PubMed ID
- 7468732
International Standard Serial Number (ISSN)
- 0002-9394
Digital Object Identifier (DOI)
- 10.1016/0002-9394(81)90171-9
Language
- eng
Conference Location
- United States