Clinicopathologic correlation of surgically removed macular hole opercula.

Journal Article (Journal Article)

PURPOSE: To determine the ultrastructural characteristic of the operculum associated with macular holes. METHODS: We developed instrumentation and a technique to capture the operculum observed with macular holes. Two opercula were studied by transmission electron microscopy. RESULTS: The two specimens were attached to a layer of native collagen identified as cortical vitreous and were composed primarily of Mueller cells and fibrous astrocytes without adjacent inner limiting membrane. No distinct retinal neuronal tissue was present. CONCLUSIONS: Our findings indicate that proliferation of fibrous astrocytes and Mueller cells occurs with the formation of a macular hole, that this reparative tissue may be dislodged, and it is the reparative tissue that previously has been interpreted as an operculum.

Full Text

Duke Authors

Cited Authors

  • Madreperla, SA; McCuen, BW; Hickingbotham, D; Green, WR

Published Date

  • August 1995

Published In

Volume / Issue

  • 120 / 2

Start / End Page

  • 197 - 207

PubMed ID

  • 7639304

International Standard Serial Number (ISSN)

  • 0002-9394

Digital Object Identifier (DOI)

  • 10.1016/s0002-9394(14)72608-x


  • eng

Conference Location

  • United States