Herpes simplex retinitis in the mouse. Clinicopathologic correlations.

Journal Article (Journal Article)

BALB/c mice inoculated with herpes simplex virus type 1 in one anterior chamber develop retinitis with subsequent retinal necrosis in the contralateral eye. The clinical features of this disease were characterized with indirect ophthalmoscopy and fundus photography. Three phases of the disease were delineated: (1) acute retinitis; (2) retinal necrosis; and (3) resolution; the clinical findings in each phase were correlated with the microscopic features. In addition, we compared the virus titers from individual animals with and without clinical evidence of retinitis to demonstrate that retinal inflammation correlated with the titer of virus in the uninoculated eye. This animal model is useful for the analysis of the clinical, virologic and immunologic manifestations of herpetic retinitis.

Full Text

Duke Authors

Cited Authors

  • Cousins, SW; Gonzalez, A; Atherton, SS

Published Date

  • July 1, 1989

Published In

Volume / Issue

  • 30 / 7

Start / End Page

  • 1485 - 1494

PubMed ID

  • 2545643

International Standard Serial Number (ISSN)

  • 0146-0404


  • eng

Conference Location

  • United States