Skip to main content
Journal cover image

Alpha-melanocyte-stimulating hormone suppresses antigen-stimulated T cell production of gamma-interferon.

Publication ,  Journal Article
Taylor, AW; Streilein, JW; Cousins, SW
Published in: Neuroimmunomodulation
1994

The neuropeptide alpha-melanocyte-stimulating hormone (alpha-MSH) is known to suppress cytokine-mediated inflammation. In addition, we previously found that alpha-MSH suppressed the production of the proinflammatory cytokine interferon (IFN)-gamma by antigen-stimulated primed lymph node T cells. This immunosuppressive activity of alpha-MSH on lymph node T cell cultures is similar to that of interleukin (IL)-4. To further examine the potential 'IL-4 like' activities of alpha-MSH, antigen-stimulated lymph node T cell cultures were treated with alpha-MSH in the presence of neutralizing anti-IL-4 antibodies. The enhanced production of IFN-gamma caused by the presence of anti-IL-4 alone in the T cell cultures was squelched by alpha-MSH. This demonstrated that in these cultures, alpha-MSH regulation of IFN-gamma production operates in a fashion similar to that of endogenous IL-4. Addition of exogenous IL-4 to antigen-stimulated lymph node T cell cultures did not intensify alpha-MSH down-regulation of IFN-gamma production, and the addition of alpha-MSH to IL-4-treated cultures did not further depress IFN-gamma production. These and the previous results suggest that the mechanism of alpha-MSH suppression of IFN-gamma production in the antigen-stimulated T cell cultures is similar to, but independent of, IL-4. When antigen-presenting cells (APCs) were the only cells in the antigen-stimulated T cell cultures treated with alpha-MSH, there was a significant reduction (60-70%) of APC elicitation of IFN-gamma production by untreated primed T cells.(ABSTRACT TRUNCATED AT 250 WORDS)

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Neuroimmunomodulation

DOI

ISSN

1021-7401

Publication Date

1994

Volume

1

Issue

3

Start / End Page

188 / 194

Location

Switzerland

Related Subject Headings

  • alpha-MSH
  • Th1 Cells
  • Neuroimmunomodulation
  • Mycobacterium tuberculosis
  • Mice, Inbred BALB C
  • Mice
  • Lymphocyte Activation
  • Lymph Nodes
  • Interferon-gamma
  • Inflammation
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Taylor, A. W., Streilein, J. W., & Cousins, S. W. (1994). Alpha-melanocyte-stimulating hormone suppresses antigen-stimulated T cell production of gamma-interferon. Neuroimmunomodulation, 1(3), 188–194. https://doi.org/10.1159/000097167
Taylor, A. W., J. W. Streilein, and S. W. Cousins. “Alpha-melanocyte-stimulating hormone suppresses antigen-stimulated T cell production of gamma-interferon.Neuroimmunomodulation 1, no. 3 (1994): 188–94. https://doi.org/10.1159/000097167.
Taylor AW, Streilein JW, Cousins SW. Alpha-melanocyte-stimulating hormone suppresses antigen-stimulated T cell production of gamma-interferon. Neuroimmunomodulation. 1994;1(3):188–94.
Taylor, A. W., et al. “Alpha-melanocyte-stimulating hormone suppresses antigen-stimulated T cell production of gamma-interferon.Neuroimmunomodulation, vol. 1, no. 3, 1994, pp. 188–94. Pubmed, doi:10.1159/000097167.
Taylor AW, Streilein JW, Cousins SW. Alpha-melanocyte-stimulating hormone suppresses antigen-stimulated T cell production of gamma-interferon. Neuroimmunomodulation. 1994;1(3):188–194.
Journal cover image

Published In

Neuroimmunomodulation

DOI

ISSN

1021-7401

Publication Date

1994

Volume

1

Issue

3

Start / End Page

188 / 194

Location

Switzerland

Related Subject Headings

  • alpha-MSH
  • Th1 Cells
  • Neuroimmunomodulation
  • Mycobacterium tuberculosis
  • Mice, Inbred BALB C
  • Mice
  • Lymphocyte Activation
  • Lymph Nodes
  • Interferon-gamma
  • Inflammation