A platform for compartmentalized protein synthesis: protein translation and translocation in the ER.
Journal Article (Journal Article;Review)
Recent advances in the study of protein translocation across the membrane of the endoplasmic reticulum include insights into the mechanism of signal-sequence function. Biochemical and genetic studies have provided further evidence that lumenal proteins perform direct roles in secretory protein translocation and in the regulation of protein-conducting-channel permeability during membrane protein integration. A hypothesis identifying the endoplasmic reticulum as a site of mRNA localization and compartmentalized protein synthesis has been suggested.
Full Text
Duke Authors
Cited Authors
- Nicchitta, CV
Published Date
- August 2002
Published In
Volume / Issue
- 14 / 4
Start / End Page
- 412 - 416
PubMed ID
- 12383790
International Standard Serial Number (ISSN)
- 0955-0674
Digital Object Identifier (DOI)
- 10.1016/s0955-0674(02)00353-8
Language
- eng
Conference Location
- England