A platform for compartmentalized protein synthesis: protein translation and translocation in the ER.

Journal Article (Review)

Recent advances in the study of protein translocation across the membrane of the endoplasmic reticulum include insights into the mechanism of signal-sequence function. Biochemical and genetic studies have provided further evidence that lumenal proteins perform direct roles in secretory protein translocation and in the regulation of protein-conducting-channel permeability during membrane protein integration. A hypothesis identifying the endoplasmic reticulum as a site of mRNA localization and compartmentalized protein synthesis has been suggested.

Full Text

Duke Authors

Cited Authors

  • Nicchitta, CV

Published Date

  • August 2002

Published In

Volume / Issue

  • 14 / 4

Start / End Page

  • 412 - 416

PubMed ID

  • 12383790

Pubmed Central ID

  • 12383790

International Standard Serial Number (ISSN)

  • 0955-0674

Digital Object Identifier (DOI)

  • 10.1016/s0955-0674(02)00353-8


  • eng

Conference Location

  • England