A platform for compartmentalized protein synthesis: protein translation and translocation in the ER.

Journal Article (Journal Article;Review)

Recent advances in the study of protein translocation across the membrane of the endoplasmic reticulum include insights into the mechanism of signal-sequence function. Biochemical and genetic studies have provided further evidence that lumenal proteins perform direct roles in secretory protein translocation and in the regulation of protein-conducting-channel permeability during membrane protein integration. A hypothesis identifying the endoplasmic reticulum as a site of mRNA localization and compartmentalized protein synthesis has been suggested.

Full Text

Duke Authors

Cited Authors

  • Nicchitta, CV

Published Date

  • August 2002

Published In

Volume / Issue

  • 14 / 4

Start / End Page

  • 412 - 416

PubMed ID

  • 12383790

Pubmed Central ID

  • 12383790

International Standard Serial Number (ISSN)

  • 0955-0674

Digital Object Identifier (DOI)

  • 10.1016/s0955-0674(02)00353-8

Language

  • eng

Conference Location

  • England