The DRiP hypothesis decennial: support, controversy, refinement and extension.

Published

Journal Article

In 1996, to explain the rapid presentation of viral proteins to CD8+ T cells, it was proposed that peptides presented by MHC class I molecules derive from defective ribosomal products (DRiPs), presumed to be polypeptides arising from in-frame translation that fail to achieve native structure owing to inevitable imperfections in transcription, translation, post-translational modifications or protein folding. Here, we consider findings that address the DRiP hypothesis, and extend the hypothesis by proposing that cells possess specialized machinery, possibly in the form of "immunoribosomes", to couple protein synthesis to antigen presentation.

Full Text

Duke Authors

Cited Authors

  • Yewdell, JW; Nicchitta, CV

Published Date

  • August 2006

Published In

Volume / Issue

  • 27 / 8

Start / End Page

  • 368 - 373

PubMed ID

  • 16815756

Pubmed Central ID

  • 16815756

Electronic International Standard Serial Number (EISSN)

  • 1471-4981

International Standard Serial Number (ISSN)

  • 1471-4906

Digital Object Identifier (DOI)

  • 10.1016/j.it.2006.06.008

Language

  • eng