The DRiP hypothesis decennial: support, controversy, refinement and extension.
Published
Journal Article
In 1996, to explain the rapid presentation of viral proteins to CD8+ T cells, it was proposed that peptides presented by MHC class I molecules derive from defective ribosomal products (DRiPs), presumed to be polypeptides arising from in-frame translation that fail to achieve native structure owing to inevitable imperfections in transcription, translation, post-translational modifications or protein folding. Here, we consider findings that address the DRiP hypothesis, and extend the hypothesis by proposing that cells possess specialized machinery, possibly in the form of "immunoribosomes", to couple protein synthesis to antigen presentation.
Full Text
Duke Authors
Cited Authors
- Yewdell, JW; Nicchitta, CV
Published Date
- August 2006
Published In
Volume / Issue
- 27 / 8
Start / End Page
- 368 - 373
PubMed ID
- 16815756
Pubmed Central ID
- 16815756
International Standard Serial Number (ISSN)
- 1471-4906
Digital Object Identifier (DOI)
- 10.1016/j.it.2006.06.008
Language
- eng
Conference Location
- England