Ribosome exchange revisited: a mechanism for translation-coupled ribosome detachment from the ER membrane.

Journal Article (Journal Article;Review)

In current models, ribosome release from the endoplasmic reticulum (ER) is coupled to the termination of protein translation. Thus, coincident with termination, membrane-bound ribosomes dissociate into their component subunits and are released into the cytosol. Here, we review past and current data and propose that the affinity of the ribosome for the ER membrane is decreased during translation, with ribosome release occurring when a membrane-bound ribosome is engaged in the synthesis of a protein lacking a signal sequence. Our model emphasizes a role for the conformation of the large ribosomal subunit in the regulation of membrane affinity and provides a mechanism for translation-coupled ribosome release.

Full Text

Duke Authors

Cited Authors

  • Potter, MD; Seiser, RM; Nicchitta, CV

Published Date

  • March 2001

Published In

Volume / Issue

  • 11 / 3

Start / End Page

  • 112 - 115

PubMed ID

  • 11306271

International Standard Serial Number (ISSN)

  • 0962-8924

Digital Object Identifier (DOI)

  • 10.1016/s0962-8924(00)01905-x


  • eng

Conference Location

  • England