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Ribosome exchange revisited: a mechanism for translation-coupled ribosome detachment from the ER membrane.

Publication ,  Journal Article
Potter, MD; Seiser, RM; Nicchitta, CV
Published in: Trends Cell Biol
March 2001

In current models, ribosome release from the endoplasmic reticulum (ER) is coupled to the termination of protein translation. Thus, coincident with termination, membrane-bound ribosomes dissociate into their component subunits and are released into the cytosol. Here, we review past and current data and propose that the affinity of the ribosome for the ER membrane is decreased during translation, with ribosome release occurring when a membrane-bound ribosome is engaged in the synthesis of a protein lacking a signal sequence. Our model emphasizes a role for the conformation of the large ribosomal subunit in the regulation of membrane affinity and provides a mechanism for translation-coupled ribosome release.

Duke Scholars

Published In

Trends Cell Biol

DOI

ISSN

0962-8924

Publication Date

March 2001

Volume

11

Issue

3

Start / End Page

112 / 115

Location

England

Related Subject Headings

  • Trans-Activators
  • Signal Recognition Particle
  • Ribosomes
  • RNA, Ribosomal
  • Protein Sorting Signals
  • Protein Biosynthesis
  • Nucleic Acid Conformation
  • Molecular Chaperones
  • Models, Molecular
  • Endoplasmic Reticulum, Rough
 

Citation

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Potter, M. D., Seiser, R. M., & Nicchitta, C. V. (2001). Ribosome exchange revisited: a mechanism for translation-coupled ribosome detachment from the ER membrane. Trends Cell Biol, 11(3), 112–115. https://doi.org/10.1016/s0962-8924(00)01905-x
Potter, M. D., R. M. Seiser, and C. V. Nicchitta. “Ribosome exchange revisited: a mechanism for translation-coupled ribosome detachment from the ER membrane.Trends Cell Biol 11, no. 3 (March 2001): 112–15. https://doi.org/10.1016/s0962-8924(00)01905-x.
Potter MD, Seiser RM, Nicchitta CV. Ribosome exchange revisited: a mechanism for translation-coupled ribosome detachment from the ER membrane. Trends Cell Biol. 2001 Mar;11(3):112–5.
Potter, M. D., et al. “Ribosome exchange revisited: a mechanism for translation-coupled ribosome detachment from the ER membrane.Trends Cell Biol, vol. 11, no. 3, Mar. 2001, pp. 112–15. Pubmed, doi:10.1016/s0962-8924(00)01905-x.
Potter MD, Seiser RM, Nicchitta CV. Ribosome exchange revisited: a mechanism for translation-coupled ribosome detachment from the ER membrane. Trends Cell Biol. 2001 Mar;11(3):112–115.
Journal cover image

Published In

Trends Cell Biol

DOI

ISSN

0962-8924

Publication Date

March 2001

Volume

11

Issue

3

Start / End Page

112 / 115

Location

England

Related Subject Headings

  • Trans-Activators
  • Signal Recognition Particle
  • Ribosomes
  • RNA, Ribosomal
  • Protein Sorting Signals
  • Protein Biosynthesis
  • Nucleic Acid Conformation
  • Molecular Chaperones
  • Models, Molecular
  • Endoplasmic Reticulum, Rough