Non-replicating mucosal and systemic vaccines: quantitative and qualitative differences in the Ag-specific CD8(+) T cell population in different tissues.

Published

Journal Article

Directed dissemination of Ag-specific CD8(+) T cells to infected organs or cancerous tissues is a prerequisite for optimal immunotherapy. Ag-specific CD8(+) T cells were quantitated in systemic and mucosal tissues after nasal, rectal, or cutaneous immunization with CTL epitope peptide and the adjuvant cholera toxin (CT). Mucosal and cutaneous immunization induced Ag-specific CD8(+) lymphocytes that were detectable in both mucosal and systemic compartments, suggesting a less strict distribution pattern than that known for B cells. However, optimal localization, activation and phenotype of these cells correlated with the route of immunization. In accordance with this observation, protection against a mucosal challenge with a virus expressing the CTL epitope was superior in mucosally-immunized animals.

Full Text

Duke Authors

Cited Authors

  • Qimron, U; Paul, L; Bar-Haim, E; Bloushtain, N; Eisenbach, L; Staats, HF; Porgador, A

Published Date

  • 2004-03-29

Published In

Volume / Issue

  • 22 / 11-12

Start / End Page

  • 1390 - 1394

PubMed ID

  • 15063561

Pubmed Central ID

  • 15063561

International Standard Serial Number (ISSN)

  • 0264-410X

Digital Object Identifier (DOI)

  • 10.1016/j.vaccine.2003.11.043

Language

  • eng

Conference Location

  • Netherlands