Identification of a new autosomal dominant limb-girdle muscular dystrophy locus on chromosome 7.

Published

Journal Article

We report the identification of a new locus for autosomal dominant limb-girdle muscular dystrophy (LGMD1) on 7q. Two of five families (1047 and 1701) demonstrate evidence in favor of linkage to this region. The maximum two-point LOD score for family 1047 was 3.76 for D7S427, and that for family 1701 was 2.63 for D7S3058. Flanking markers place the LGMD1 locus between D7S2423 and D7S427, with multipoint analysis slightly favoring the 9-cM interval spanned by D7S2546 and D7S2423. Three of five families appear to be unlinked to this new locus on chromosome 7, thus establishing further heterogeneity within the LGMD1 diagnostic classification.

Full Text

Duke Authors

Cited Authors

  • Speer, MC; Vance, JM; Grubber, JM; Lennon Graham, F; Stajich, JM; Viles, KD; Rogala, A; McMichael, R; Chutkow, J; Goldsmith, C; Tim, RW; Pericak-Vance, MA

Published Date

  • February 1999

Published In

Volume / Issue

  • 64 / 2

Start / End Page

  • 556 - 562

PubMed ID

  • 9973293

Pubmed Central ID

  • 9973293

International Standard Serial Number (ISSN)

  • 0002-9297

Digital Object Identifier (DOI)

  • 10.1086/302252

Language

  • eng

Conference Location

  • United States