Systematic gene mapping in man: data management considerations.

Published

Journal Article

The application of recombinant DNA technology to linkage analysis is revolutionizing the gene mapping field through the availability of an increasing number of restriction fragment length polymorphisms (RFLP). The successful mapping of the human genome will lead to a new era of research in human genetics with implications for carrier detection and prenatal diagnosis in any number of disorders. In addition, the development of RFLP tightly linked to a disease is critical for the potential identification of the genetic defect. A systematic approach to human gene mapping whereby it is possible to simultaneously screen several disorders for linkage is discussed. Guidelines for the database management, field studies, DNA and lymphoblast cell transformation, family history and laboratory data are included. This methodology represents the integration and application of statistical and molecular genetic, clinical and tissue culture expertise to human gene mapping.

Full Text

Duke Authors

Cited Authors

  • Pericak-Vance, MA; Hung, WY; Yamaoka, L; Haynes, C; Bartlett, RJ; Vance, JM; Lee, J; Siddique, T; Gaskell, PC; Stajich, J

Published Date

  • January 1988

Published In

Volume / Issue

  • 24 Suppl 1 /

Start / End Page

  • 87 - 89

PubMed ID

  • 2904804

Pubmed Central ID

  • 2904804

International Standard Serial Number (ISSN)

  • 0004-993X

Language

  • eng