Linkage of a gene for macular corneal dystrophy to chromosome 16.
Publication
, Journal Article
Vance, JM; Jonasson, F; Lennon, F; Sarrica, J; Damji, KF; Stauffer, J; Pericak-Vance, MA; Klintworth, GK
Published in: Am J Hum Genet
April 1996
Autosomal recessive macular corneal dystrophy (MCD) is a heterogeneous disorder leading to visual impairment. Sixteen American and Icelandic families (11 type I and 5 type II) were analyzed for linkage, by use of 208 polymorphic microsatellite markers. A significant maximum LOD score Zmax of 7.82 at a maximum recombination fraction (thetamax) of .06 was found with the 16q22 locus D16S518 for MCD type I. In addition, a peak LOD score of 2.50 at a recombination fraction of .00 was obtained for the MCD type II families, by use of the identical marker. These findings raise the possibility that MCD type II may be due to the same genetic locus that is involved in MCD type I.
Duke Scholars
Published In
Am J Hum Genet
ISSN
0002-9297
Publication Date
April 1996
Volume
58
Issue
4
Start / End Page
757 / 762
Location
United States
Related Subject Headings
- Pedigree
- Male
- Iceland
- Humans
- Genetics & Heredity
- Genetic Linkage
- Genetic Heterogeneity
- Female
- Corneal Dystrophies, Hereditary
- Chromosomes, Human, Pair 16
Citation
APA
Chicago
ICMJE
MLA
NLM
Vance, J. M., Jonasson, F., Lennon, F., Sarrica, J., Damji, K. F., Stauffer, J., … Klintworth, G. K. (1996). Linkage of a gene for macular corneal dystrophy to chromosome 16. Am J Hum Genet, 58(4), 757–762.
Vance, J. M., F. Jonasson, F. Lennon, J. Sarrica, K. F. Damji, J. Stauffer, M. A. Pericak-Vance, and G. K. Klintworth. “Linkage of a gene for macular corneal dystrophy to chromosome 16.” Am J Hum Genet 58, no. 4 (April 1996): 757–62.
Vance JM, Jonasson F, Lennon F, Sarrica J, Damji KF, Stauffer J, et al. Linkage of a gene for macular corneal dystrophy to chromosome 16. Am J Hum Genet. 1996 Apr;58(4):757–62.
Vance, J. M., et al. “Linkage of a gene for macular corneal dystrophy to chromosome 16.” Am J Hum Genet, vol. 58, no. 4, Apr. 1996, pp. 757–62.
Vance JM, Jonasson F, Lennon F, Sarrica J, Damji KF, Stauffer J, Pericak-Vance MA, Klintworth GK. Linkage of a gene for macular corneal dystrophy to chromosome 16. Am J Hum Genet. 1996 Apr;58(4):757–762.
Published In
Am J Hum Genet
ISSN
0002-9297
Publication Date
April 1996
Volume
58
Issue
4
Start / End Page
757 / 762
Location
United States
Related Subject Headings
- Pedigree
- Male
- Iceland
- Humans
- Genetics & Heredity
- Genetic Linkage
- Genetic Heterogeneity
- Female
- Corneal Dystrophies, Hereditary
- Chromosomes, Human, Pair 16