Confirmation of genetic heterogeneity in limb-girdle muscular dystrophy: linkage of an autosomal dominant form to chromosome 5q.


Journal Article

Limb-girdle muscular dystrophy (LGMD) is a clinically and genetically heterogenous group of disorders, with both recessive and dominant forms reported. Recently, a series of recessive LGMD families were linked to chromosome 15q. We report herein the results of our linkage studies in a previously reported large autosomal dominant family. The LGMD gene in this family was localized to chromosome 5q22.3-31.3 by using a series of CA(n) microsatellite repeat markers. Linkage to 15q was excluded. These findings confirm genetic heterogeneity in this clinically diverse syndrome.

Full Text

Cited Authors

  • Speer, MC; Yamaoka, LH; Gilchrist, JH; Gaskell, CP; Stajich, JM; Vance, JM; Kazantsev, A; Lastra, AA; Haynes, CS; Beckmann, JS

Published Date

  • June 1992

Published In

Volume / Issue

  • 50 / 6

Start / End Page

  • 1211 - 1217

PubMed ID

  • 1598902

Pubmed Central ID

  • 1598902

Electronic International Standard Serial Number (EISSN)

  • 1537-6605

International Standard Serial Number (ISSN)

  • 0002-9297


  • eng