Heterogeneity in Paget disease of the bone.
Paget disease of the bone is a common skeletal disorder. Recently, a gene for Paget disease was localized to 18q with subsequent evidence for linkage heterogeneity. We report the identification and clinical characterization of a large pedigree of Paget disease and demonstrate that the Paget disease gene in this pedigree is not linked to the region on 18q, thus confirming linkage heterogeneity.
Nance, MA; Nuttall, FQ; Econs, MJ; Lyles, KW; Viles, KD; Vance, JM; Pericak-Vance, MA; Speer, MC
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