Carcinoma of the tonsillar region: a multivariate analysis of 243 patients treated with radical radiotherapy.

Journal Article (Journal Article)

Between October 1964 and June 1990, 243 patients with squamous cell carcinoma of the tonsillar region were treated with continuous-course radical radiotherapy at the University of Florida. All patients had a minimum 2-year follow-up. Patients were staged according to the AJCC system; stage IV was stratified into two subsets: favorable, IVA (T1-T3 or N2A-N3A); and unfavorable, IVB (T4 or N3B). The initial and ultimate local control rates (including surgical salvage) according to T stage were as follows: T1, 87% and 100%, T2, 79% and 92%; T3, 71% and 76%; and T4, 44% and 48%. Multivariate analysis demonstrated that anterior extension of the primary tumor (p = .0001) and T stage (p = .014) were the most significant parameters affecting local control after radiotherapy. For T4 lesions, twice-daily irradiation significantly improved local control (p = .04). The 5-year absolute and cause-specific survival rates as a function of modified AJCC stage were as follows: I, 37% and 100%; II, 55% and 90%; III, 55% and 85%; IVA, 35% and 60%; and IVB, 23% and 38%. The probability of a severe complication was 3% for the entire group of patients.

Full Text

Duke Authors

Cited Authors

  • Lee, WR; Mendenhall, WM; Parsons, JT; Million, RR; Cassisi, NJ; Stringer, SP

Published Date

  • July 1993

Published In

Volume / Issue

  • 15 / 4

Start / End Page

  • 283 - 288

PubMed ID

  • 8360047

International Standard Serial Number (ISSN)

  • 1043-3074

Digital Object Identifier (DOI)

  • 10.1002/hed.2880150402


  • eng

Conference Location

  • United States