CD8+ T cell mediated noncytolytic inhibition of human immunodeficiency virus type I.

Published online

Journal Article (Review)

The development of cellular immune responses in primary human immunodeficiency virus type-1 (HIV-1) infection is accompanied by a dramatic decrease in plasma viremia and resolution of the acute clinical syndrome. The full nature of the immunological response and its consequences on HIV pathogenesis is still largely a mystery, but significant progress has been achieved in the characterization of some of the players involved. Several studies indicate that noncytolytic HIV suppression by CD8+ T lymphocytes may be inversely associated with viral load suggesting that this antiviral activity is important in host control of HIV replication. This review focuses on this antiviral activity by CD8+ T lymphocytes, which is distinct from that activity elicited by some cytolytic CD8+ T lymphocytes (CTLs).

Full Text

Duke Authors

Cited Authors

  • Tomaras, GD; Greenberg, ML

Published Date

  • March 1, 2001

Published In

Volume / Issue

  • 6 /

Start / End Page

  • D575 - D598

PubMed ID

  • 11229882

Pubmed Central ID

  • 11229882

International Standard Serial Number (ISSN)

  • 1093-9946

Digital Object Identifier (DOI)

  • 10.2741/tomaras


  • eng

Conference Location

  • United States