How cells get the right chromosomes.

Journal Article (Review;Journal Article)

When cells divide, the chromosomes must be delivered flawlessly to the daughter cells. Missing or extra chromosomes can result in birth defects and cancer. Chance events are the starting point for chromosome delivery, which makes the process prone to error. Errors are avoided by diverse uses of mechanical tension from mitotic forces. Tension stabilizes the proper chromosome configuration, controls a cell cycle checkpoint, and changes chromosome chemistry.

Full Text

Duke Authors

Cited Authors

  • Nicklas, RB

Published Date

  • January 1997

Published In

Volume / Issue

  • 275 / 5300

Start / End Page

  • 632 - 637

PubMed ID

  • 9005842

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.275.5300.632


  • eng