How cells get the right chromosomes.
Publication
, Journal Article
Nicklas, RB
Published in: Science (New York, N.Y.)
January 1997
When cells divide, the chromosomes must be delivered flawlessly to the daughter cells. Missing or extra chromosomes can result in birth defects and cancer. Chance events are the starting point for chromosome delivery, which makes the process prone to error. Errors are avoided by diverse uses of mechanical tension from mitotic forces. Tension stabilizes the proper chromosome configuration, controls a cell cycle checkpoint, and changes chromosome chemistry.
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Published In
Science (New York, N.Y.)
DOI
EISSN
1095-9203
ISSN
0036-8075
Publication Date
January 1997
Volume
275
Issue
5300
Start / End Page
632 / 637
Related Subject Headings
- Stress, Mechanical
- Spindle Apparatus
- Selection, Genetic
- Phosphorylation
- Nuclear Proteins
- Mitosis
- Microtubules
- Meiosis
- Kinetochores
- Humans
Citation
APA
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ICMJE
MLA
NLM
Nicklas, R. B. (1997). How cells get the right chromosomes. Science (New York, N.Y.), 275(5300), 632–637. https://doi.org/10.1126/science.275.5300.632
Nicklas, R. B. “How cells get the right chromosomes.” Science (New York, N.Y.) 275, no. 5300 (January 1997): 632–37. https://doi.org/10.1126/science.275.5300.632.
Nicklas RB. How cells get the right chromosomes. Science (New York, NY). 1997 Jan;275(5300):632–7.
Nicklas, R. B. “How cells get the right chromosomes.” Science (New York, N.Y.), vol. 275, no. 5300, Jan. 1997, pp. 632–37. Epmc, doi:10.1126/science.275.5300.632.
Nicklas RB. How cells get the right chromosomes. Science (New York, NY). 1997 Jan;275(5300):632–637.
Published In
Science (New York, N.Y.)
DOI
EISSN
1095-9203
ISSN
0036-8075
Publication Date
January 1997
Volume
275
Issue
5300
Start / End Page
632 / 637
Related Subject Headings
- Stress, Mechanical
- Spindle Apparatus
- Selection, Genetic
- Phosphorylation
- Nuclear Proteins
- Mitosis
- Microtubules
- Meiosis
- Kinetochores
- Humans