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Evaluation of piroxantrone in women with metastatic breast cancer and failure on nonanthracycline chemotherapy.

Publication ,  Journal Article
Ingle, JN; Kuross, SA; Mailliard, JA; Loprinzi, CL; Jung, SH; Nelimark, RA; Krook, JE; Long, HJ
Published in: Cancer
September 15, 1994

BACKGROUND: Doxorubicin generally is considered to be the most effective single chemotherapeutic agent for the treatment of breast cancer. The major cumulative dose-limiting toxicity is cardiac toxicity, which may be related to the formation of free radicals with subsequent lipid peroxidation, leading to membrane damage. The anthrapyrazoles, of which piroxantrone is a member, were synthesized in an attempt to eliminate this toxicity. METHODS: A Phase II clinical trial was conducted in 30 women with metastatic breast cancer in whom piroxantrone was administered at a dose of 160 mg/m2 by 1-hour infusion. The planned cycle length for retreatment was 3 weeks. Measurable metastatic disease and failure on one prior chemotherapy regimen, but no prior anthracycline exposure, were required for response evaluation. RESULTS: Twenty-nine patients were evaluable for response, and 6 (21% and 95% confidence intervals: 10-43%) achieved an objective response (1 complete, 5 partial responses), with a median response duration of 244 days. The median time-to-disease progression for all patients was 124 days. Eight patients received cumulative doses of piroxantrone approaching or exceeding 1000 mg/m2, and all had reductions in the resting left ventricular ejection fraction (LVEF). The estimated median decrease in LVEF at 1000 mg/m2 was 16%, with a range of 10-28%. Clinical findings of congestive heart failure developed in two patients. CONCLUSIONS: Piroxantrone had definite antitumor activity in women who had metastatic breast cancer and failure on prior chemotherapy that did not include an anthracycline. The 95% confidence interval for response probability was broad, but the level of activity observed was relatively low. The clear association with cardiac toxicity combined with the relatively low efficacy led to the conclusion that piroxantrone cannot be recommended for further development as therapy for women with breast cancer. Further study of other anthrapyrazoles is necessary to determine if the promise of this new class of agents can be fulfilled.

Duke Scholars

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

September 15, 1994

Volume

74

Issue

6

Start / End Page

1733 / 1738

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Pyrazoles
  • Oncology & Carcinogenesis
  • Middle Aged
  • Humans
  • Female
  • Breast Neoplasms
  • Antineoplastic Agents
  • Anthraquinones
  • Aged, 80 and over
 

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Ingle, J. N., Kuross, S. A., Mailliard, J. A., Loprinzi, C. L., Jung, S. H., Nelimark, R. A., … Long, H. J. (1994). Evaluation of piroxantrone in women with metastatic breast cancer and failure on nonanthracycline chemotherapy. Cancer, 74(6), 1733–1738. https://doi.org/10.1002/1097-0142(19940915)74:6<1733::aid-cncr2820740615>3.0.co;2-d
Ingle, J. N., S. A. Kuross, J. A. Mailliard, C. L. Loprinzi, S. H. Jung, R. A. Nelimark, J. E. Krook, and H. J. Long. “Evaluation of piroxantrone in women with metastatic breast cancer and failure on nonanthracycline chemotherapy.Cancer 74, no. 6 (September 15, 1994): 1733–38. https://doi.org/10.1002/1097-0142(19940915)74:6<1733::aid-cncr2820740615>3.0.co;2-d.
Ingle JN, Kuross SA, Mailliard JA, Loprinzi CL, Jung SH, Nelimark RA, et al. Evaluation of piroxantrone in women with metastatic breast cancer and failure on nonanthracycline chemotherapy. Cancer. 1994 Sep 15;74(6):1733–8.
Ingle, J. N., et al. “Evaluation of piroxantrone in women with metastatic breast cancer and failure on nonanthracycline chemotherapy.Cancer, vol. 74, no. 6, Sept. 1994, pp. 1733–38. Pubmed, doi:10.1002/1097-0142(19940915)74:6<1733::aid-cncr2820740615>3.0.co;2-d.
Ingle JN, Kuross SA, Mailliard JA, Loprinzi CL, Jung SH, Nelimark RA, Krook JE, Long HJ. Evaluation of piroxantrone in women with metastatic breast cancer and failure on nonanthracycline chemotherapy. Cancer. 1994 Sep 15;74(6):1733–1738.
Journal cover image

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

September 15, 1994

Volume

74

Issue

6

Start / End Page

1733 / 1738

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Pyrazoles
  • Oncology & Carcinogenesis
  • Middle Aged
  • Humans
  • Female
  • Breast Neoplasms
  • Antineoplastic Agents
  • Anthraquinones
  • Aged, 80 and over