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The use of multiattribute decision models in evaluating triptan treatment options in migraine.

Publication ,  Journal Article
Ferrari, MD; Goadsby, PJ; Lipton, RB; Dodick, DW; Cutrer, FM; McCrory, D; Williams, P
Published in: J Neurol
September 2005

BACKGROUND: The physician treating patients with migraine is now able to choose from among seven triptans-almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan and zolmitriptan. These differ, to greater or lesser degrees, on a range of clinical attributes important for treatment selection. OBJECTIVE: To outline the basic principles of Multiattribute Decision Making (MADM) and describe how one such method-TOPSIS (Technique for Order Preference by Similarity to the Ideal Solution)-can be applied to evaluate the currently available triptans. METHODS: In an example application, summary data from a recent meta-analysis of 53 published and unpublished placebo-controlled trials of the oral triptans were combined in TOPSIS models with computer-generated attribute importance weights representing the entire range of possible values, That is, the relative performance of the triptans was explored across all logically possible combinations of relative importance of the treatment attributes available from the meta-analysis, and uncertainty was assessed based on the confidence intervals from the meta-analysis. RESULTS: When compared across the entire range of values for relative attribute importance, almotriptan, eletriptan and rizatriptan were more similar to a hypothetical ideal triptan and were more likely to appear in the top three closest to the hypothetical ideal, than were naratriptan, sumatriptan, and zolmitriptan. CONCLUSION: Using the TOPSIS model, almotriptan, eletriptan and rizatriptan were more likely to appear in the top three closest to the hypothetical ideal triptan.

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Published In

J Neurol

DOI

ISSN

0340-5354

Publication Date

September 2005

Volume

252

Issue

9

Start / End Page

1026 / 1032

Location

Germany

Related Subject Headings

  • Tryptamines
  • Neurology & Neurosurgery
  • Migraine Disorders
  • Humans
  • Decision Support Techniques
  • Clinical Trials as Topic
  • 1109 Neurosciences
  • 1103 Clinical Sciences
 

Citation

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Ferrari, M. D., Goadsby, P. J., Lipton, R. B., Dodick, D. W., Cutrer, F. M., McCrory, D., & Williams, P. (2005). The use of multiattribute decision models in evaluating triptan treatment options in migraine. J Neurol, 252(9), 1026–1032. https://doi.org/10.1007/s00415-005-0769-0
Ferrari, M. D., P. J. Goadsby, R. B. Lipton, D. W. Dodick, F. M. Cutrer, D. McCrory, and P. Williams. “The use of multiattribute decision models in evaluating triptan treatment options in migraine.J Neurol 252, no. 9 (September 2005): 1026–32. https://doi.org/10.1007/s00415-005-0769-0.
Ferrari MD, Goadsby PJ, Lipton RB, Dodick DW, Cutrer FM, McCrory D, et al. The use of multiattribute decision models in evaluating triptan treatment options in migraine. J Neurol. 2005 Sep;252(9):1026–32.
Ferrari, M. D., et al. “The use of multiattribute decision models in evaluating triptan treatment options in migraine.J Neurol, vol. 252, no. 9, Sept. 2005, pp. 1026–32. Pubmed, doi:10.1007/s00415-005-0769-0.
Ferrari MD, Goadsby PJ, Lipton RB, Dodick DW, Cutrer FM, McCrory D, Williams P. The use of multiattribute decision models in evaluating triptan treatment options in migraine. J Neurol. 2005 Sep;252(9):1026–1032.
Journal cover image

Published In

J Neurol

DOI

ISSN

0340-5354

Publication Date

September 2005

Volume

252

Issue

9

Start / End Page

1026 / 1032

Location

Germany

Related Subject Headings

  • Tryptamines
  • Neurology & Neurosurgery
  • Migraine Disorders
  • Humans
  • Decision Support Techniques
  • Clinical Trials as Topic
  • 1109 Neurosciences
  • 1103 Clinical Sciences