Review of newer antifungal and immunomodulatory strategies for invasive aspergillosis.


Journal Article (Review)

The incidence of invasive aspergillosis is markedly increasing, and mortality remains dismal. Previously there were only 2 antifungals with activity against Aspergillus, but over the last few years there has been an explosion of newer agents and reformulations of older antifungals. Exploration has also begun with immunotherapy, with use of cytokines and granulocyte transfusions alone or in combination with antifungal therapy. This review will detail the available in vitro, in vivo, and clinical experience with the newer antifungal and immunomodulatory therapies in development for treatment of invasive aspergillosis.

Full Text

Duke Authors

Cited Authors

  • Steinbach, WJ; Stevens, DA

Published Date

  • October 1, 2003

Published In

Volume / Issue

  • 37 Suppl 3 /

Start / End Page

  • S157 - S187

PubMed ID

  • 12975751

Pubmed Central ID

  • 12975751

Electronic International Standard Serial Number (EISSN)

  • 1537-6591

Digital Object Identifier (DOI)

  • 10.1086/376523


  • eng

Conference Location

  • United States