Combination antifungal therapy for invasive aspergillosis: utilizing new targeting strategies.

Published

Journal Article (Review)

The optimal therapy for invasive aspergillosis (IA) is unknown, and there is little agreement on the exact antifungal management of IA. The previously stagnant landscape of antifungal choices for IA is rapidly changing with newer antifungals and newer targets. While amphotericin B has historically been the preferred therapy, recent studies support voriconazole as primary therapy or caspofungin as salvage therapy. However, even these newer therapies have only elevated clinical response rates to approximately 50%. Recent in vitro studies, animal models, and limited clinical reports suggest that combination antifungal therapy utilizing novel targeting strategies might offer improved outcome. Until very recently, combination antifungal therapy for IA was of little consequence since there were a limited number of possible permutations available. There has been a great deal of new data published exploring the possibilities of combination therapy, but clinicians need to be aware of the potential advantages and disadvantages of combination antifungal therapy for IA.

Full Text

Duke Authors

Cited Authors

  • Steinbach, WJ

Published Date

  • September 2005

Published In

Volume / Issue

  • 5 / 3

Start / End Page

  • 203 - 210

PubMed ID

  • 16181140

Pubmed Central ID

  • 16181140

International Standard Serial Number (ISSN)

  • 1568-0053

Digital Object Identifier (DOI)

  • 10.2174/1568005054880145

Language

  • eng