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Assessment of whole-brain vasodilatory capacity with acetazolamide challenge at 1.5 T using dynamic contrast imaging with frequency-shifted burst.

Publication ,  Journal Article
Petrella, JR; DeCarli, C; Dagli, M; Duyn, JH; Grandin, CB; Frank, JA; Hoffman, EA; Theodore, WH
Published in: AJNR Am J Neuroradiol
1997

PURPOSE: To determine whether whole-brain acetazolamide-induced changes in regional cerebral blood volume (rCBV) can be assessed on a conventional gradient 1.5-T MR system using 3-D dynamic susceptibility contrast-enhanced MR imaging. METHODS: A 3-D frequency-shifted (FS) burst technique was used to assess the intravascular first pass of contrast agent. Changes in rCBV were calculated in 40 volunteers before and after acetazolamide (n = 30) or saline (n = 10) injection using customized analysis software on an independent workstation. A single-section gradient-echo technique with better spatial resolution was used in one additional volunteer to examine the effect of partial volume averaging on calculation of absolute rCBV. RESULTS: A statistically significant increase in rCBV (gray matter = 23%, white master = 32.5%) was noted after acetazolamide compared with saline. Baseline fractional CBVs were 22% +/- 3% for gray matter and 12% +/- 2% for white matter. Partial volume averaging was probably responsible for a systematic but linear overestimation of absolute rCBV. CONCLUSION: Acetazolamide-induced changes in rCBV can be assessed using 3-D dynamic susceptibility contrast-enhanced MR imaging with FS-burst on a conventional gradient 1.5-T MR system. Values obtained with this technique overestimate absolute rCBV but are systematically biased and can be used for intersubject and intrasubject ratio comparisons.

Duke Scholars

Published In

AJNR Am J Neuroradiol

ISSN

0195-6108

Publication Date

1997

Volume

18

Issue

6

Start / End Page

1153 / 1161

Location

United States

Related Subject Headings

  • Vasodilator Agents
  • Vasodilation
  • Regional Blood Flow
  • Pentetic Acid
  • Organometallic Compounds
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Meglumine
  • Male
  • Magnetic Resonance Imaging
 

Citation

APA
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ICMJE
MLA
NLM
Petrella, J. R., DeCarli, C., Dagli, M., Duyn, J. H., Grandin, C. B., Frank, J. A., … Theodore, W. H. (1997). Assessment of whole-brain vasodilatory capacity with acetazolamide challenge at 1.5 T using dynamic contrast imaging with frequency-shifted burst. AJNR Am J Neuroradiol, 18(6), 1153–1161.
Petrella, J. R., C. DeCarli, M. Dagli, J. H. Duyn, C. B. Grandin, J. A. Frank, E. A. Hoffman, and W. H. Theodore. “Assessment of whole-brain vasodilatory capacity with acetazolamide challenge at 1.5 T using dynamic contrast imaging with frequency-shifted burst.AJNR Am J Neuroradiol 18, no. 6 (1997): 1153–61.
Petrella JR, DeCarli C, Dagli M, Duyn JH, Grandin CB, Frank JA, et al. Assessment of whole-brain vasodilatory capacity with acetazolamide challenge at 1.5 T using dynamic contrast imaging with frequency-shifted burst. AJNR Am J Neuroradiol. 1997;18(6):1153–61.
Petrella JR, DeCarli C, Dagli M, Duyn JH, Grandin CB, Frank JA, Hoffman EA, Theodore WH. Assessment of whole-brain vasodilatory capacity with acetazolamide challenge at 1.5 T using dynamic contrast imaging with frequency-shifted burst. AJNR Am J Neuroradiol. 1997;18(6):1153–1161.

Published In

AJNR Am J Neuroradiol

ISSN

0195-6108

Publication Date

1997

Volume

18

Issue

6

Start / End Page

1153 / 1161

Location

United States

Related Subject Headings

  • Vasodilator Agents
  • Vasodilation
  • Regional Blood Flow
  • Pentetic Acid
  • Organometallic Compounds
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Meglumine
  • Male
  • Magnetic Resonance Imaging