In vivo amyloid imaging in Alzheimer's disease.

Published

Journal Article (Review)

Targeted approaches to therapy for Alzheimer's disease have evolved based on detailed understanding of the genetic, molecular biologic, and neuropathologic basis of the disease. Given the potential for greater treatment efficacy in the earlier stages of the disease, the notion of early diagnosis has become more relevant. Current clinical and imaging diagnostic approaches lack reliability in the preclinical and prodromal phases of the disease. We review emerging studies on imaging of the molecular substrate of the disease, most notably the amyloid peptide, which hope to increase early diagnostic efficacy. We offer a brief overview of the demographics, diagnostic criteria, and current imaging tests, followed by a review of amyloid biology and developments in cerebral amyloid imaging yielded by recent in vitro, in vivo and human studies.

Full Text

Duke Authors

Cited Authors

  • Sair, HI; Doraiswamy, PM; Petrella, JR

Published Date

  • February 2004

Published In

Volume / Issue

  • 46 / 2

Start / End Page

  • 93 - 104

PubMed ID

  • 14740203

Pubmed Central ID

  • 14740203

Electronic International Standard Serial Number (EISSN)

  • 1432-1920

International Standard Serial Number (ISSN)

  • 0028-3940

Digital Object Identifier (DOI)

  • 10.1007/s00234-003-1034-9

Language

  • eng